node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akp3 | Alpi | ENSRNOP00000071091 | ENSRNOP00000026190 | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | 0.541 |
Akp3 | Alpp | ENSRNOP00000071091 | ENSRNOP00000026095 | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | Alkaline phosphatase. | 0.408 |
Akp3 | Gch1 | ENSRNOP00000071091 | ENSRNOP00000014821 | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.901 |
Akp3 | Pts | ENSRNOP00000071091 | ENSRNOP00000012434 | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.900 |
Alpi | Akp3 | ENSRNOP00000026190 | ENSRNOP00000071091 | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | 0.541 |
Alpi | Alpp | ENSRNOP00000026190 | ENSRNOP00000026095 | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | Alkaline phosphatase. | 0.407 |
Alpi | Gch1 | ENSRNOP00000026190 | ENSRNOP00000014821 | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.903 |
Alpi | Pts | ENSRNOP00000026190 | ENSRNOP00000012434 | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.900 |
Alpl | Gch1 | ENSRNOP00000019004 | ENSRNOP00000014821 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.901 |
Alpl | Pts | ENSRNOP00000019004 | ENSRNOP00000012434 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.900 |
Alpp | Akp3 | ENSRNOP00000026095 | ENSRNOP00000071091 | Alkaline phosphatase. | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | 0.408 |
Alpp | Alpi | ENSRNOP00000026095 | ENSRNOP00000026190 | Alkaline phosphatase. | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | 0.407 |
Alpp | Gch1 | ENSRNOP00000026095 | ENSRNOP00000014821 | Alkaline phosphatase. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.901 |
Alpp | Pts | ENSRNOP00000026095 | ENSRNOP00000012434 | Alkaline phosphatase. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.900 |
Gch1 | Akp3 | ENSRNOP00000014821 | ENSRNOP00000071091 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Intestinal-type alkaline phosphatase 2; Belongs to the alkaline phosphatase family. | 0.901 |
Gch1 | Alpi | ENSRNOP00000014821 | ENSRNOP00000026190 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Intestinal-type alkaline phosphatase 1; Belongs to the alkaline phosphatase family. | 0.903 |
Gch1 | Alpl | ENSRNOP00000014821 | ENSRNOP00000019004 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | 0.901 |
Gch1 | Alpp | ENSRNOP00000014821 | ENSRNOP00000026095 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase. | 0.901 |
Gch1 | Gchfr | ENSRNOP00000014821 | ENSRNOP00000016458 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. | 0.998 |
Gch1 | Itpa | ENSRNOP00000014821 | ENSRNOP00000028838 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.947 |