node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arsa | Arsb | ENSRNOP00000017782 | ENSRNOP00000014860 | Arylsulfatase A, isoform CRA_a. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | 0.949 |
Arsa | Arsg | ENSRNOP00000017782 | ENSRNOP00000005257 | Arylsulfatase A, isoform CRA_a. | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | 0.914 |
Arsa | Idua | ENSRNOP00000017782 | ENSRNOP00000000048 | Arylsulfatase A, isoform CRA_a. | Alpha-L-iduronidase. | 0.640 |
Arsa | Spam1 | ENSRNOP00000017782 | ENSRNOP00000009537 | Arylsulfatase A, isoform CRA_a. | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). | 0.536 |
Arsa | Sumf1 | ENSRNOP00000017782 | ENSRNOP00000009008 | Arylsulfatase A, isoform CRA_a. | Sulfatase modifying factor 1 (Predicted). | 0.909 |
Arsb | Arsa | ENSRNOP00000014860 | ENSRNOP00000017782 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Arylsulfatase A, isoform CRA_a. | 0.949 |
Arsb | Arsg | ENSRNOP00000014860 | ENSRNOP00000005257 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | 0.939 |
Arsb | Hyal1 | ENSRNOP00000014860 | ENSRNOP00000021408 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.931 |
Arsb | Hyal2 | ENSRNOP00000014860 | ENSRNOP00000075204 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family. | 0.917 |
Arsb | Hyal4 | ENSRNOP00000014860 | ENSRNOP00000072978 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.911 |
Arsb | Hyal5 | ENSRNOP00000014860 | ENSRNOP00000057222 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.914 |
Arsb | Hyal6 | ENSRNOP00000014860 | ENSRNOP00000009405 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase. | 0.908 |
Arsb | Idua | ENSRNOP00000014860 | ENSRNOP00000000048 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Alpha-L-iduronidase. | 0.969 |
Arsb | Spam1 | ENSRNOP00000014860 | ENSRNOP00000009537 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). | 0.908 |
Arsb | Sumf1 | ENSRNOP00000014860 | ENSRNOP00000009008 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Sulfatase modifying factor 1 (Predicted). | 0.904 |
Arsg | Arsa | ENSRNOP00000005257 | ENSRNOP00000017782 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | Arylsulfatase A, isoform CRA_a. | 0.914 |
Arsg | Arsb | ENSRNOP00000005257 | ENSRNOP00000014860 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | 0.939 |
Arsg | Idua | ENSRNOP00000005257 | ENSRNOP00000000048 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | Alpha-L-iduronidase. | 0.487 |
Arsg | Sumf1 | ENSRNOP00000005257 | ENSRNOP00000009008 | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. | Sulfatase modifying factor 1 (Predicted). | 0.732 |
Hyal1 | Arsb | ENSRNOP00000021408 | ENSRNOP00000014860 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | 0.931 |