node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asb8 | Iqca1l | ENSRNOP00000013704 | ENSRNOP00000014998 | Ankyrin repeat and SOCS box-containing protein 8 (Predicted), isoform CRA_a. | IQ and AAA domain-containing protein 1-like. | 0.497 |
Chmp3 | Iqca1l | ENSRNOP00000010253 | ENSRNOP00000014998 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | IQ and AAA domain-containing protein 1-like. | 0.485 |
Chmp3 | Ist1 | ENSRNOP00000010253 | ENSRNOP00000020365 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.934 |
Iqca1l | Asb8 | ENSRNOP00000014998 | ENSRNOP00000013704 | IQ and AAA domain-containing protein 1-like. | Ankyrin repeat and SOCS box-containing protein 8 (Predicted), isoform CRA_a. | 0.497 |
Iqca1l | Chmp3 | ENSRNOP00000014998 | ENSRNOP00000010253 | IQ and AAA domain-containing protein 1-like. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.485 |
Iqca1l | Ist1 | ENSRNOP00000014998 | ENSRNOP00000020365 | IQ and AAA domain-containing protein 1-like. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.468 |
Iqca1l | LOC100911374 | ENSRNOP00000014998 | ENSRNOP00000072788 | IQ and AAA domain-containing protein 1-like. | UBX domain-containing protein 7-like. | 0.802 |
Iqca1l | Lrrc14b | ENSRNOP00000014998 | ENSRNOP00000032819 | IQ and AAA domain-containing protein 1-like. | Similar to LOC432779 protein (Predicted). | 0.547 |
Iqca1l | Lrrc39 | ENSRNOP00000014998 | ENSRNOP00000020297 | IQ and AAA domain-containing protein 1-like. | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. | 0.508 |
Iqca1l | Plaa | ENSRNOP00000014998 | ENSRNOP00000010621 | IQ and AAA domain-containing protein 1-like. | Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor ne [...] | 0.517 |
Iqca1l | Ubxn1 | ENSRNOP00000014998 | ENSRNOP00000026651 | IQ and AAA domain-containing protein 1-like. | UBX domain-containing protein 1; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'- linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1- BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). | 0.467 |
Iqca1l | Ubxn7 | ENSRNOP00000014998 | ENSRNOP00000066087 | IQ and AAA domain-containing protein 1-like. | UBX domain-containing protein 7. | 0.802 |
Iqca1l | Ufd1 | ENSRNOP00000014998 | ENSRNOP00000067081 | IQ and AAA domain-containing protein 1-like. | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] | 0.568 |
Ist1 | Chmp3 | ENSRNOP00000020365 | ENSRNOP00000010253 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.934 |
Ist1 | Iqca1l | ENSRNOP00000020365 | ENSRNOP00000014998 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | IQ and AAA domain-containing protein 1-like. | 0.468 |
LOC100911374 | Iqca1l | ENSRNOP00000072788 | ENSRNOP00000014998 | UBX domain-containing protein 7-like. | IQ and AAA domain-containing protein 1-like. | 0.802 |
LOC100911374 | Plaa | ENSRNOP00000072788 | ENSRNOP00000010621 | UBX domain-containing protein 7-like. | Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor ne [...] | 0.721 |
LOC100911374 | Ubxn1 | ENSRNOP00000072788 | ENSRNOP00000026651 | UBX domain-containing protein 7-like. | UBX domain-containing protein 1; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'- linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1- BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). | 0.983 |
LOC100911374 | Ufd1 | ENSRNOP00000072788 | ENSRNOP00000067081 | UBX domain-containing protein 7-like. | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] | 0.984 |
Lrrc14b | Iqca1l | ENSRNOP00000032819 | ENSRNOP00000014998 | Similar to LOC432779 protein (Predicted). | IQ and AAA domain-containing protein 1-like. | 0.547 |