STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BlkTyrosine-protein kinase. (499 aa)    
Predicted Functional Partners:
Cd19
CD19 molecule.
   
 
 0.859
Fcrla
Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis.
   
 
 0.748
Egfr
Receptor protein-tyrosine kinase.
    
 
0.687
Cd79b
B29/Ig-beta/CD79b.
   
 
 0.663
Bdnf
Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]
    
 
 0.606
Cd79a
Ig-like domain-containing protein.
   
 
 0.602
Bank1
B-cell scaffold protein with ankyrin repeats 1.
   
 
 0.601
Cd79al
Cd79a molecule-like.
   
 
 0.598
Ntf3
Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons.
   
 
 0.560
Lrrc61
Leucine-rich repeat-containing 61.
    
 
 0.555
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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