node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adipoq | Cfd | ENSRNOP00000002492 | ENSRNOP00000015029 | Adiponectin, C1Q and collagen domain-containing. | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.994 |
Adipoq | Fabp4 | ENSRNOP00000002492 | ENSRNOP00000073333 | Adiponectin, C1Q and collagen domain-containing. | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.869 |
Adipoq | Lep | ENSRNOP00000002492 | ENSRNOP00000066184 | Adiponectin, C1Q and collagen domain-containing. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.976 |
Adipoq | Retn | ENSRNOP00000002492 | ENSRNOP00000073327 | Adiponectin, C1Q and collagen domain-containing. | Resistin. | 0.978 |
C3 | C4b | ENSRNOP00000066885 | ENSRNOP00000037902 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.925 |
C3 | Cfb | ENSRNOP00000066885 | ENSRNOP00000000477 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement factor B, isoform CRA_b; Belongs to the peptidase S1 family. | 0.990 |
C3 | Cfb-2 | ENSRNOP00000066885 | ENSRNOP00000059051 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement factor B; Belongs to the peptidase S1 family. | 0.782 |
C3 | Cfd | ENSRNOP00000066885 | ENSRNOP00000015029 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.977 |
C3 | Cfp | ENSRNOP00000066885 | ENSRNOP00000031039 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Properdin factor, complement (Mapped). | 0.968 |
C4a | C4b | ENSRNOP00000066721 | ENSRNOP00000037902 | Complement C4A. | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.971 |
C4a | Cfb | ENSRNOP00000066721 | ENSRNOP00000000477 | Complement C4A. | Complement factor B, isoform CRA_b; Belongs to the peptidase S1 family. | 0.812 |
C4a | Cfb-2 | ENSRNOP00000066721 | ENSRNOP00000059051 | Complement C4A. | Complement factor B; Belongs to the peptidase S1 family. | 0.610 |
C4a | Cfd | ENSRNOP00000066721 | ENSRNOP00000015029 | Complement C4A. | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.748 |
C4a | Cfp | ENSRNOP00000066721 | ENSRNOP00000031039 | Complement C4A. | Properdin factor, complement (Mapped). | 0.741 |
C4b | C3 | ENSRNOP00000037902 | ENSRNOP00000066885 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.925 |
C4b | C4a | ENSRNOP00000037902 | ENSRNOP00000066721 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Complement C4A. | 0.971 |
C4b | Cfb | ENSRNOP00000037902 | ENSRNOP00000000477 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Complement factor B, isoform CRA_b; Belongs to the peptidase S1 family. | 0.954 |
C4b | Cfb-2 | ENSRNOP00000037902 | ENSRNOP00000059051 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Complement factor B; Belongs to the peptidase S1 family. | 0.902 |
C4b | Cfd | ENSRNOP00000037902 | ENSRNOP00000015029 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family. | 0.777 |
C4b | Cfp | ENSRNOP00000037902 | ENSRNOP00000031039 | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | Properdin factor, complement (Mapped). | 0.763 |