STRINGSTRING
Pragmin protein (Rattus norvegicus) - STRING interaction network
"Pragmin" - Similar to DNA segment, Chr 8, ERATO Doi 82, expressed in Rattus norvegicus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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PragminSimilar to DNA segment, Chr 8, ERATO Doi 82, expressed (Predicted), isoform CRA_a; Pragma of Rnd2 (1368 aa)    
Predicted Functional Partners:
Hmces
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells. May act as a peptidase; experimental evidences are however required to confirm this prediction (By similarity) (353 aa)
           
  0.676
Mtmr9
Myotubularin related protein 9; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily (549 aa)
           
  0.584
Mtmr7
Myotubularin related protein 7; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily (419 aa)
           
  0.538
Sgcz
Sarcoglycan zeta (237 aa)
           
  0.538
Mpzl1
Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. May be involved in regulation of integrin- mediated cell motility (By similarity); Belongs to the myelin P0 protein family (270 aa)
           
  0.524
Csk
Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or ada [...] (450 aa)
       
 
  0.513
Fnbp1
Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By s [...] (612 aa)
           
  0.499
Shb
Src homology 2 domain containing adaptor protein B (501 aa)
           
  0.407
Bud13
BUD13 homolog (S. cerevisiae); Belongs to the CWC26 family (636 aa)
           
  0.404
Rpain
RPA-interacting protein; Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity) (219 aa)
           
  0.404
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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