node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fras1 | Lrrc10 | ENSRNOP00000002814 | ENSRNOP00000007338 | Fraser extracellular matrix complex subunit 1 | Leucine-rich repeat-containing protein 10-like | 0.521 |
Fras1 | Lrrc26 | ENSRNOP00000002814 | ENSRNOP00000015242 | Fraser extracellular matrix complex subunit 1 | Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity) | 0.521 |
Fras1 | Sspo | ENSRNOP00000002814 | ENSRNOP00000037189 | Fraser extracellular matrix complex subunit 1 | SCO-spondin; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity) | 0.948 |
Fras1 | rCG_48832 | ENSRNOP00000002814 | ENSRNOP00000067755 | Fraser extracellular matrix complex subunit 1 | Leucine-rich repeat-containing protein 10-like; Leucine-rich repeat-containing 10 | 0.521 |
Kcna6 | Kcnma1 | ENSRNOP00000067348 | ENSRNOP00000058962 | Potassium voltage-gated channel shaker-related subfamily a member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other [...] | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | 0.776 |
Kcna6 | Kcnmb1 | ENSRNOP00000067348 | ENSRNOP00000007408 | Potassium voltage-gated channel shaker-related subfamily a member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other [...] | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | 0.606 |
Kcna6 | Lrrc26 | ENSRNOP00000067348 | ENSRNOP00000015242 | Potassium voltage-gated channel shaker-related subfamily a member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other [...] | Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity) | 0.571 |
Kcnma1 | Kcna6 | ENSRNOP00000058962 | ENSRNOP00000067348 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Potassium voltage-gated channel shaker-related subfamily a member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other [...] | 0.776 |
Kcnma1 | Kcnmb1 | ENSRNOP00000058962 | ENSRNOP00000007408 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | 0.993 |
Kcnma1 | Kcnmb2 | ENSRNOP00000058962 | ENSRNOP00000013410 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Potassium large conductance calcium-activated channel subfamily m beta member 2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity) | 0.926 |
Kcnma1 | Kcnmb4 | ENSRNOP00000058962 | ENSRNOP00000038834 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Potassium large conductance calcium-activated channel subfamily m beta member 4; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concent [...] | 0.982 |
Kcnma1 | Kcnu1 | ENSRNOP00000058962 | ENSRNOP00000019935 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Potassium large conductance calcium-activated channel subfamily m alpha member 3; Potassium channel, subfamily U, member 1; Belongs to the potassium channel family | 0.812 |
Kcnma1 | Lrrc26 | ENSRNOP00000058962 | ENSRNOP00000015242 | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity) | 0.840 |
Kcnmb1 | Kcna6 | ENSRNOP00000007408 | ENSRNOP00000067348 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Potassium voltage-gated channel shaker-related subfamily a member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other [...] | 0.606 |
Kcnmb1 | Kcnma1 | ENSRNOP00000007408 | ENSRNOP00000058962 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | 0.993 |
Kcnmb1 | Kcnmb2 | ENSRNOP00000007408 | ENSRNOP00000013410 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Potassium large conductance calcium-activated channel subfamily m beta member 2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity) | 0.814 |
Kcnmb1 | Kcnmb4 | ENSRNOP00000007408 | ENSRNOP00000038834 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Potassium large conductance calcium-activated channel subfamily m beta member 4; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concent [...] | 0.856 |
Kcnmb1 | Kcnu1 | ENSRNOP00000007408 | ENSRNOP00000019935 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Potassium large conductance calcium-activated channel subfamily m alpha member 3; Potassium channel, subfamily U, member 1; Belongs to the potassium channel family | 0.911 |
Kcnmb1 | Lrrc26 | ENSRNOP00000007408 | ENSRNOP00000015242 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] | Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity) | 0.802 |
Kcnmb2 | Kcnma1 | ENSRNOP00000013410 | ENSRNOP00000058962 | Potassium large conductance calcium-activated channel subfamily m beta member 2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity) | Potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Belongs to the potassium channel family | 0.926 |