node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asns | Ctps2 | ENSRNOP00000010079 | ENSRNOP00000055810 | Asparagine synthetase [glutamine-hydrolyzing]. | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | 0.543 |
Asns | Fads6 | ENSRNOP00000010079 | ENSRNOP00000036480 | Asparagine synthetase [glutamine-hydrolyzing]. | Fatty acid desaturase domain family, member 6 (Predicted). | 0.658 |
Asns | Fdxr | ENSRNOP00000010079 | ENSRNOP00000075248 | Asparagine synthetase [glutamine-hydrolyzing]. | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. | 0.658 |
Asns | Gls2 | ENSRNOP00000010079 | ENSRNOP00000018737 | Asparagine synthetase [glutamine-hydrolyzing]. | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.404 |
Asns | Glud1 | ENSRNOP00000010079 | ENSRNOP00000075032 | Asparagine synthetase [glutamine-hydrolyzing]. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.816 |
Asns | Gmps | ENSRNOP00000010079 | ENSRNOP00000072183 | Asparagine synthetase [glutamine-hydrolyzing]. | GMP synthase [glutamine-hydrolyzing]. | 0.708 |
Asns | Lgsn | ENSRNOP00000010079 | ENSRNOP00000016316 | Asparagine synthetase [glutamine-hydrolyzing]. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). | 0.758 |
Asns | Tmem109 | ENSRNOP00000010079 | ENSRNOP00000036054 | Asparagine synthetase [glutamine-hydrolyzing]. | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro. | 0.732 |
Ctps2 | Asns | ENSRNOP00000055810 | ENSRNOP00000010079 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | Asparagine synthetase [glutamine-hydrolyzing]. | 0.543 |
Ctps2 | Fads6 | ENSRNOP00000055810 | ENSRNOP00000036480 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | Fatty acid desaturase domain family, member 6 (Predicted). | 0.445 |
Ctps2 | Fdxr | ENSRNOP00000055810 | ENSRNOP00000075248 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. | 0.445 |
Ctps2 | Glud1 | ENSRNOP00000055810 | ENSRNOP00000075032 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.621 |
Ctps2 | Gmps | ENSRNOP00000055810 | ENSRNOP00000072183 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | GMP synthase [glutamine-hydrolyzing]. | 0.919 |
Ctps2 | Lgsn | ENSRNOP00000055810 | ENSRNOP00000016316 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). | 0.791 |
Ctps2 | Tmem109 | ENSRNOP00000055810 | ENSRNOP00000036054 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro. | 0.556 |
Fads6 | Asns | ENSRNOP00000036480 | ENSRNOP00000010079 | Fatty acid desaturase domain family, member 6 (Predicted). | Asparagine synthetase [glutamine-hydrolyzing]. | 0.658 |
Fads6 | Ctps2 | ENSRNOP00000036480 | ENSRNOP00000055810 | Fatty acid desaturase domain family, member 6 (Predicted). | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). | 0.445 |
Fads6 | Gls | ENSRNOP00000036480 | ENSRNOP00000071972 | Fatty acid desaturase domain family, member 6 (Predicted). | Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Belongs to the glutaminase family. | 0.566 |
Fads6 | Gls2 | ENSRNOP00000036480 | ENSRNOP00000018737 | Fatty acid desaturase domain family, member 6 (Predicted). | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Belongs to the glutaminase family. | 0.585 |
Fads6 | Glud1 | ENSRNOP00000036480 | ENSRNOP00000075032 | Fatty acid desaturase domain family, member 6 (Predicted). | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. | 0.842 |