STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slc35e1Solute carrier family 35 member E1; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily. (409 aa)    
Predicted Functional Partners:
Slc35c2
Solute carrier family 35, member C2, isoform CRA_b.
   
  
0.595
Mavs
Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that [...]
   
    0.544
Slc35a5
Similar to solute carrier family 35, member A5 (Predicted).
   
  
 0.535
Slc35d1
Solute carrier family 35 member D1.
      
 0.533
Slc35b3
Solute carrier family 35 member B3.
   
 
 0.521
Slc35d3
Solute carrier family 35, member D3 (Predicted).
      
 0.516
Slc35f1
Solute carrier family 35, member F1.
   
  
 0.513
Slc35g1
Solute carrier family 35, member G1.
      
 0.499
Slc35c1
Solute carrier family 35, member C1 (Predicted), isoform CRA_a.
   
  
 0.490
Slc35b2
D-serine modulator-1, isoform CRA_b.
   
 
 0.485
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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