node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mcm2 | Mcm3 | ENSRNOP00000022231 | ENSRNOP00000017081 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm2 | Mcm7 | ENSRNOP00000022231 | ENSRNOP00000001825 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
Mcm2 | Pola1 | ENSRNOP00000022231 | ENSRNOP00000018147 | DNA helicase; Belongs to the MCM family. | DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA p [...] | 0.980 |
Mcm2 | Pola2 | ENSRNOP00000022231 | ENSRNOP00000028406 | DNA helicase; Belongs to the MCM family. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymer [...] | 0.875 |
Mcm2 | Pold1 | ENSRNOP00000022231 | ENSRNOP00000026797 | DNA helicase; Belongs to the MCM family. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.968 |
Mcm2 | Pole | ENSRNOP00000022231 | ENSRNOP00000058920 | DNA helicase; Belongs to the MCM family. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.993 |
Mcm2 | Pole2 | ENSRNOP00000022231 | ENSRNOP00000005835 | DNA helicase; Belongs to the MCM family. | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. | 0.983 |
Mcm2 | Prim1 | ENSRNOP00000022231 | ENSRNOP00000062827 | DNA helicase; Belongs to the MCM family. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.844 |
Mcm2 | Prim2 | ENSRNOP00000022231 | ENSRNOP00000016828 | DNA helicase; Belongs to the MCM family. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity) [...] | 0.946 |
Mcm2 | Rev3l | ENSRNOP00000022231 | ENSRNOP00000054053 | DNA helicase; Belongs to the MCM family. | REV3-like, DNA directed polymerase zeta catalytic subunit. | 0.740 |
Mcm3 | Mcm2 | ENSRNOP00000017081 | ENSRNOP00000022231 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
Mcm3 | Mcm7 | ENSRNOP00000017081 | ENSRNOP00000001825 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
Mcm3 | Pola1 | ENSRNOP00000017081 | ENSRNOP00000018147 | DNA helicase; Belongs to the MCM family. | DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA p [...] | 0.965 |
Mcm3 | Pola2 | ENSRNOP00000017081 | ENSRNOP00000028406 | DNA helicase; Belongs to the MCM family. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymer [...] | 0.870 |
Mcm3 | Pold1 | ENSRNOP00000017081 | ENSRNOP00000026797 | DNA helicase; Belongs to the MCM family. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.927 |
Mcm3 | Pole | ENSRNOP00000017081 | ENSRNOP00000058920 | DNA helicase; Belongs to the MCM family. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.985 |
Mcm3 | Pole2 | ENSRNOP00000017081 | ENSRNOP00000005835 | DNA helicase; Belongs to the MCM family. | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. | 0.990 |
Mcm3 | Prim1 | ENSRNOP00000017081 | ENSRNOP00000062827 | DNA helicase; Belongs to the MCM family. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.867 |
Mcm3 | Prim2 | ENSRNOP00000017081 | ENSRNOP00000016828 | DNA helicase; Belongs to the MCM family. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity) [...] | 0.950 |
Mcm3 | Rev3l | ENSRNOP00000017081 | ENSRNOP00000054053 | DNA helicase; Belongs to the MCM family. | REV3-like, DNA directed polymerase zeta catalytic subunit. | 0.742 |