node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chm | Rab23 | ENSRNOP00000000174 | ENSRNOP00000072716 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | RAB23, member RAS oncogene family (Predicted). | 0.598 |
Chm | Rabggta | ENSRNOP00000000174 | ENSRNOP00000049261 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | 0.996 |
Cplane2 | Ift22 | ENSRNOP00000074971 | ENSRNOP00000041226 | Similar to novel protein (Predicted), isoform CRA_b. | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B. | 0.534 |
Cplane2 | Rab23 | ENSRNOP00000074971 | ENSRNOP00000072716 | Similar to novel protein (Predicted), isoform CRA_b. | RAB23, member RAS oncogene family (Predicted). | 0.705 |
Gli2 | Gli3 | ENSRNOP00000009963 | ENSRNOP00000019396 | GLI family zinc finger 2. | GLI family zinc finger 3. | 0.924 |
Gli2 | Rab23 | ENSRNOP00000009963 | ENSRNOP00000072716 | GLI family zinc finger 2. | RAB23, member RAS oncogene family (Predicted). | 0.657 |
Gli2 | Smo | ENSRNOP00000009963 | ENSRNOP00000011356 | GLI family zinc finger 2. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. | 0.967 |
Gli2 | Sufu | ENSRNOP00000009963 | ENSRNOP00000026987 | GLI family zinc finger 2. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
Gli2 | Tulp3 | ENSRNOP00000009963 | ENSRNOP00000007634 | GLI family zinc finger 2. | Tubby-like protein; Belongs to the TUB family. | 0.425 |
Gli3 | Gli2 | ENSRNOP00000019396 | ENSRNOP00000009963 | GLI family zinc finger 3. | GLI family zinc finger 2. | 0.924 |
Gli3 | Rab23 | ENSRNOP00000019396 | ENSRNOP00000072716 | GLI family zinc finger 3. | RAB23, member RAS oncogene family (Predicted). | 0.627 |
Gli3 | Smo | ENSRNOP00000019396 | ENSRNOP00000011356 | GLI family zinc finger 3. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. | 0.947 |
Gli3 | Sufu | ENSRNOP00000019396 | ENSRNOP00000026987 | GLI family zinc finger 3. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.998 |
Gli3 | Tulp3 | ENSRNOP00000019396 | ENSRNOP00000007634 | GLI family zinc finger 3. | Tubby-like protein; Belongs to the TUB family. | 0.492 |
Ift22 | Cplane2 | ENSRNOP00000041226 | ENSRNOP00000074971 | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B. | Similar to novel protein (Predicted), isoform CRA_b. | 0.534 |
Ift22 | Rab23 | ENSRNOP00000041226 | ENSRNOP00000072716 | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B. | RAB23, member RAS oncogene family (Predicted). | 0.637 |
Kif17 | Rab23 | ENSRNOP00000020215 | ENSRNOP00000072716 | Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | RAB23, member RAS oncogene family (Predicted). | 0.600 |
Rab23 | Chm | ENSRNOP00000072716 | ENSRNOP00000000174 | RAB23, member RAS oncogene family (Predicted). | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | 0.598 |
Rab23 | Cplane2 | ENSRNOP00000072716 | ENSRNOP00000074971 | RAB23, member RAS oncogene family (Predicted). | Similar to novel protein (Predicted), isoform CRA_b. | 0.705 |
Rab23 | Gli2 | ENSRNOP00000072716 | ENSRNOP00000009963 | RAB23, member RAS oncogene family (Predicted). | GLI family zinc finger 2. | 0.657 |