STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pxylp12-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation duri [...] (480 aa)    
Predicted Functional Partners:
Extl2
Exostoses (Multiple)-like 2, isoform CRA_a.
   
  
 0.711
Fam20b
FAM20B, glycosaminoglycan xylosylkinase.
      
 0.683
Nwd2
NACHT and WD repeat domain-containing 2.
  
   
 0.673
Ext2
Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family.
   
  
 0.617
Mcc-2
MCC regulator of WNT-signaling pathway.
      
 0.613
Nek10
NIMA-related kinase 10.
      
 0.590
Mcc
MCC regulator of WNT-signaling pathway.
      
 0.583
Scml4
Scm polycomb group protein-like 4.
      
 0.583
B3gat3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.
      
 0.554
Atad2b
ATPase family, AAA domain-containing 2B.
      
 0.547
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (26%) [HD]