node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gch1 | Gucy1a1 | ENSRNOP00000014821 | ENSRNOP00000017190 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.814 |
Gch1 | Gucy1a2 | ENSRNOP00000014821 | ENSRNOP00000040361 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | 0.810 |
Gch1 | Gucy1b1 | ENSRNOP00000014821 | ENSRNOP00000062785 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. | 0.809 |
Gch1 | Gucy1b2 | ENSRNOP00000014821 | ENSRNOP00000012948 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Guanylate cyclase soluble subunit beta-2. | 0.811 |
Gch1 | Itpa | ENSRNOP00000014821 | ENSRNOP00000028838 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.947 |
Gucy1a1 | Gch1 | ENSRNOP00000017190 | ENSRNOP00000014821 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.814 |
Gucy1a1 | Gucy1a2 | ENSRNOP00000017190 | ENSRNOP00000040361 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | 0.842 |
Gucy1a1 | Gucy1b1 | ENSRNOP00000017190 | ENSRNOP00000062785 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. | 0.999 |
Gucy1a1 | Gucy1b2 | ENSRNOP00000017190 | ENSRNOP00000012948 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanylate cyclase soluble subunit beta-2. | 0.967 |
Gucy1a1 | Itpa | ENSRNOP00000017190 | ENSRNOP00000028838 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.919 |
Gucy1a1 | Nos1 | ENSRNOP00000017190 | ENSRNOP00000062735 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum; Belongs to the NOS family. | 0.919 |
Gucy1a1 | Pde2a | ENSRNOP00000017190 | ENSRNOP00000026586 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. | 0.812 |
Gucy1a1 | Pde5a | ENSRNOP00000017190 | ENSRNOP00000019637 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. | 0.872 |
Gucy1a1 | Pde9a | ENSRNOP00000017190 | ENSRNOP00000001559 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its abi [...] | 0.823 |
Gucy1a1 | Prkg2 | ENSRNOP00000017190 | ENSRNOP00000003237 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (Probable). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal- regulated kinases MAPK3/ERK1 AND MAPK1/ERK2 in mechanically st [...] | 0.954 |
Gucy1a2 | Gch1 | ENSRNOP00000040361 | ENSRNOP00000014821 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.810 |
Gucy1a2 | Gucy1a1 | ENSRNOP00000040361 | ENSRNOP00000017190 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.842 |
Gucy1a2 | Gucy1b1 | ENSRNOP00000040361 | ENSRNOP00000062785 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. | 0.976 |
Gucy1a2 | Gucy1b2 | ENSRNOP00000040361 | ENSRNOP00000012948 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | Guanylate cyclase soluble subunit beta-2. | 0.929 |
Gucy1a2 | Itpa | ENSRNOP00000040361 | ENSRNOP00000028838 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.902 |