node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arsb | Gusb | ENSRNOP00000014860 | ENSRNOP00000045033 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | 0.696 |
Arsb | Hyal1 | ENSRNOP00000014860 | ENSRNOP00000021408 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.931 |
Arsb | Idua | ENSRNOP00000014860 | ENSRNOP00000000048 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | Alpha-L-iduronidase. | 0.969 |
Cd44 | Habp2 | ENSRNOP00000009000 | ENSRNOP00000045891 | CD44 antigen. | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | 0.577 |
Cd44 | Has1 | ENSRNOP00000009000 | ENSRNOP00000014824 | CD44 antigen. | Hyaluronan synthase 1. | 0.617 |
Cd44 | Has2 | ENSRNOP00000009000 | ENSRNOP00000006517 | CD44 antigen. | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] | 0.810 |
Cd44 | Has3 | ENSRNOP00000009000 | ENSRNOP00000075458 | CD44 antigen. | Hyaluronan synthase 3. | 0.785 |
Cd44 | Hmmr | ENSRNOP00000009000 | ENSRNOP00000070444 | CD44 antigen. | Hyaluronan-mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity (By similarity). May act as a regulator of adipogenisis (By similarity). | 0.960 |
Cd44 | Hyal1 | ENSRNOP00000009000 | ENSRNOP00000021408 | CD44 antigen. | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.696 |
Gusb | Arsb | ENSRNOP00000045033 | ENSRNOP00000014860 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). | 0.696 |
Gusb | Hyal1 | ENSRNOP00000045033 | ENSRNOP00000021408 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.941 |
Gusb | Idua | ENSRNOP00000045033 | ENSRNOP00000000048 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. | Alpha-L-iduronidase. | 0.732 |
Habp2 | Cd44 | ENSRNOP00000045891 | ENSRNOP00000009000 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | CD44 antigen. | 0.577 |
Habp2 | Has1 | ENSRNOP00000045891 | ENSRNOP00000014824 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | Hyaluronan synthase 1. | 0.591 |
Habp2 | Has2 | ENSRNOP00000045891 | ENSRNOP00000006517 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] | 0.727 |
Habp2 | Has3 | ENSRNOP00000045891 | ENSRNOP00000075458 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | Hyaluronan synthase 3. | 0.642 |
Habp2 | Hmmr | ENSRNOP00000045891 | ENSRNOP00000070444 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | Hyaluronan-mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity (By similarity). May act as a regulator of adipogenisis (By similarity). | 0.532 |
Habp2 | Hyal1 | ENSRNOP00000045891 | ENSRNOP00000021408 | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model. | 0.606 |
Has1 | Cd44 | ENSRNOP00000014824 | ENSRNOP00000009000 | Hyaluronan synthase 1. | CD44 antigen. | 0.617 |
Has1 | Habp2 | ENSRNOP00000014824 | ENSRNOP00000045891 | Hyaluronan synthase 1. | Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. | 0.591 |