node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |

Akr1c3 | Akr1d1 | ENSRNOP00000023739 | ENSRNOP00000017675 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 0.927 |

Akr1c3 | Cyp17a1 | ENSRNOP00000023739 | ENSRNOP00000027160 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | 0.942 |

Akr1c3 | ENSRNOG00000046795 | ENSRNOP00000023739 | ENSRNOP00000064259 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | Steroid 5-alpha-reductase type 2 | 0.938 |

Akr1c3 | Hsd3b | ENSRNOP00000023739 | ENSRNOP00000053018 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 | 0.968 |

Akr1c3 | Hsd3b5 | ENSRNOP00000023739 | ENSRNOP00000026290 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 3 beta-hydroxysteroid dehydrogenase type 5 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase | 0.959 |

Akr1c3 | Hsd3b7 | ENSRNOP00000023739 | ENSRNOP00000025933 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 3 beta-hydroxysteroid dehydrogenase type 7 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (By similarity) | 0.485 |

Akr1c3 | Srd5a1 | ENSRNOP00000023739 | ENSRNOP00000023659 | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 ; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.972 |

Akr1d1 | Akr1c3 | ENSRNOP00000017675 | ENSRNOP00000023739 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 0.927 |

Akr1d1 | Cyp17a1 | ENSRNOP00000017675 | ENSRNOP00000027160 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | 0.922 |

Akr1d1 | Cyp19a1 | ENSRNOP00000017675 | ENSRNOP00000000212 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | Cytochrome P450 19A1 ; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | 0.921 |

Akr1d1 | Cyp8b1 | ENSRNOP00000017675 | ENSRNOP00000026355 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor | 0.927 |

Akr1d1 | ENSRNOG00000046795 | ENSRNOP00000017675 | ENSRNOP00000064259 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | Steroid 5-alpha-reductase type 2 | 0.938 |

Akr1d1 | Hsd3b | ENSRNOP00000017675 | ENSRNOP00000053018 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 | 0.949 |

Akr1d1 | Hsd3b5 | ENSRNOP00000017675 | ENSRNOP00000026290 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 3 beta-hydroxysteroid dehydrogenase type 5 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase | 0.952 |

Akr1d1 | Hsd3b7 | ENSRNOP00000017675 | ENSRNOP00000025933 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 3 beta-hydroxysteroid dehydrogenase type 7 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (By similarity) | 0.961 |

Akr1d1 | Srd5a1 | ENSRNOP00000017675 | ENSRNOP00000023659 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 ; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology | 0.961 |

Akr1d1 | Ugt2a1 | ENSRNOP00000017675 | ENSRNOP00000040239 | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | UDP glucuronosyltransferase 2 family, polypeptide A1 | 0.921 |

Cyp17a1 | Akr1c3 | ENSRNOP00000027160 | ENSRNOP00000023739 | Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) | 0.942 |

Cyp17a1 | Akr1d1 | ENSRNOP00000027160 | ENSRNOP00000017675 | Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | 3-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates | 0.922 |

Cyp17a1 | Cyp19a1 | ENSRNOP00000027160 | ENSRNOP00000000212 | Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | Cytochrome P450 19A1 ; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | 0.942 |