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Akr1d1 protein (Rattus norvegicus) - STRING interaction network
"Akr1d1" - 3-oxo-5-beta-steroid 4-dehydrogenase in Rattus norvegicus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Akr1d13-oxo-5-beta-steroid 4-dehydrogenase ; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates (324 aa)    
Predicted Functional Partners:
Srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 ; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (258 aa)
     
 
  0.961
Hsd3b7
3 beta-hydroxysteroid dehydrogenase type 7 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (By similarity) (338 aa)
   
 
  0.961
Hsd3b5
3 beta-hydroxysteroid dehydrogenase type 5 ; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase (373 aa)
   
 
  0.952
Hsd3b
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 (373 aa)
   
 
  0.949
ENSRNOG00000046795
Steroid 5-alpha-reductase type 2 (93 aa)
     
 
    0.938
Akr1c3
Aldo-keto reductase family 1 member C18 ; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP) (323 aa)
   
0.927
Cyp8b1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor (499 aa)
     
 
  0.927
Cyp17a1
Steroid 17-alpha-hydroxylase/17,20 lyase ; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty (507 aa)
     
 
  0.922
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1 (532 aa)
     
 
  0.921
Cyp19a1
Cytochrome P450 19A1 ; Catalyzes the formation of aromatic C18 estrogens from C19 androgens (503 aa)
     
 
  0.921
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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