STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mctp1Multiple C2 and transmembrane domain-containing protein 1; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (By similarity). Overexpression in cultured neurons significantly inhibits neuronal transferrin endocytosis, secretory vesicle retrieval, cell migration, and oxidative stress from glutamate toxicity. (946 aa)    
Predicted Functional Partners:
Efcab11
EF-hand calcium-binding domain-containing protein 11.
      
 0.716
Iqck
IQ motif-containing K.
      
 0.645
Map4k3
Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity).
   
  
 0.525
Prr32
Proline-rich 32.
      
 0.518
Fam172a
Similar to Sperm 1 POU-domain transcription factor (SPRM-1) (Predicted).
      
 0.504
Defb9
Beta-defensin 9; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.497
Pdzd4
PDZ domain-containing 4.
      
 0.495
Adgre1
Adhesion G protein-coupled receptor E2; Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.
      
 0.494
Fer1l5
Fer-1-like family member 5.
      
 0.491
Frrs1
Ferric-chelate reductase 1.
      
 0.489
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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