node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B2m | Calr3 | ENSRNOP00000023017 | ENSRNOP00000018018 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Calreticulin. | 0.878 |
B2m | Canx | ENSRNOP00000023017 | ENSRNOP00000040859 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | 0.903 |
B2m | Hspa5 | ENSRNOP00000023017 | ENSRNOP00000025064 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.659 |
B2m | Pdia3 | ENSRNOP00000023017 | ENSRNOP00000020478 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Protein disulfide-isomerase A3. | 0.992 |
B2m | Pdia4 | ENSRNOP00000023017 | ENSRNOP00000008728 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. | 0.431 |
B2m | Tapbp | ENSRNOP00000023017 | ENSRNOP00000045630 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | Tap-binding protein (Tapasin). | 0.994 |
Calr3 | B2m | ENSRNOP00000018018 | ENSRNOP00000023017 | Calreticulin. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.878 |
Calr3 | Canx | ENSRNOP00000018018 | ENSRNOP00000040859 | Calreticulin. | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | 0.987 |
Calr3 | Hsp90b1 | ENSRNOP00000018018 | ENSRNOP00000034846 | Calreticulin. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. | 0.983 |
Calr3 | Hspa4 | ENSRNOP00000018018 | ENSRNOP00000023628 | Calreticulin. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.863 |
Calr3 | Hspa5 | ENSRNOP00000018018 | ENSRNOP00000025064 | Calreticulin. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.976 |
Calr3 | Hyou1 | ENSRNOP00000018018 | ENSRNOP00000039172 | Calreticulin. | Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity). | 0.900 |
Calr3 | Pdia3 | ENSRNOP00000018018 | ENSRNOP00000020478 | Calreticulin. | Protein disulfide-isomerase A3. | 0.999 |
Calr3 | Pdia4 | ENSRNOP00000018018 | ENSRNOP00000008728 | Calreticulin. | Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. | 0.900 |
Calr3 | Tapbp | ENSRNOP00000018018 | ENSRNOP00000045630 | Calreticulin. | Tap-binding protein (Tapasin). | 0.997 |
Calr3 | Thbs1 | ENSRNOP00000018018 | ENSRNOP00000069322 | Calreticulin. | Thrombospondin 1. | 0.905 |
Canx | B2m | ENSRNOP00000040859 | ENSRNOP00000023017 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | 0.903 |
Canx | Calr3 | ENSRNOP00000040859 | ENSRNOP00000018018 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Calreticulin. | 0.987 |
Canx | Hsp90b1 | ENSRNOP00000040859 | ENSRNOP00000034846 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. | 0.973 |
Canx | Hspa4 | ENSRNOP00000040859 | ENSRNOP00000023628 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.818 |