node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef7 | Iqgap1 | ENSRNOP00000043761 | ENSRNOP00000018021 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | 0.629 |
Arhgef7 | Myo9a | ENSRNOP00000043761 | ENSRNOP00000015963 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). | 0.486 |
Arhgef7 | Nck1 | ENSRNOP00000043761 | ENSRNOP00000020330 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | NCK adaptor protein 1. | 0.886 |
Arhgef7 | Pak4 | ENSRNOP00000043761 | ENSRNOP00000076081 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Non-specific serine/threonine protein kinase. | 0.691 |
Arhgef7 | Pak6 | ENSRNOP00000043761 | ENSRNOP00000075254 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Non-specific serine/threonine protein kinase. | 0.695 |
Arhgef7 | Pard6a | ENSRNOP00000043761 | ENSRNOP00000069044 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. | 0.485 |
Arhgef7 | Pard6b | ENSRNOP00000043761 | ENSRNOP00000014568 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Par-6 (Partitioning defective 6) homolog beta (C. elegans) (Predicted). | 0.411 |
Arhgef7 | Rhov | ENSRNOP00000043761 | ENSRNOP00000018277 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. | 0.794 |
Iqgap1 | Arhgef7 | ENSRNOP00000018021 | ENSRNOP00000043761 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). | 0.629 |
Iqgap1 | Itsn2 | ENSRNOP00000018021 | ENSRNOP00000065329 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Intersectin 2. | 0.477 |
Iqgap1 | Myo9a | ENSRNOP00000018021 | ENSRNOP00000015963 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). | 0.467 |
Iqgap1 | Nck1 | ENSRNOP00000018021 | ENSRNOP00000020330 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | NCK adaptor protein 1. | 0.613 |
Iqgap1 | Pak4 | ENSRNOP00000018021 | ENSRNOP00000076081 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Non-specific serine/threonine protein kinase. | 0.598 |
Iqgap1 | Pak6 | ENSRNOP00000018021 | ENSRNOP00000075254 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Non-specific serine/threonine protein kinase. | 0.748 |
Iqgap1 | Pard6a | ENSRNOP00000018021 | ENSRNOP00000069044 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. | 0.537 |
Iqgap1 | Pard6b | ENSRNOP00000018021 | ENSRNOP00000014568 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Par-6 (Partitioning defective 6) homolog beta (C. elegans) (Predicted). | 0.422 |
Iqgap1 | Rhov | ENSRNOP00000018021 | ENSRNOP00000018277 | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. | 0.720 |
Itsn1 | Itsn2 | ENSRNOP00000044773 | ENSRNOP00000065329 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | Intersectin 2. | 0.618 |
Itsn1 | Rhov | ENSRNOP00000044773 | ENSRNOP00000018277 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. | 0.798 |
Itsn2 | Iqgap1 | ENSRNOP00000065329 | ENSRNOP00000018021 | Intersectin 2. | IQ motif containing GTPase activating protein 1 (Predicted), isoform CRA_b. | 0.477 |