node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Exo1 | Fancm | ENSRNOP00000073202 | ENSRNOP00000074177 | Exonuclease 1. | FA complementation group M. | 0.833 |
Exo1 | Mlh1 | ENSRNOP00000073202 | ENSRNOP00000072285 | Exonuclease 1. | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | 0.968 |
Exo1 | Mlh3 | ENSRNOP00000073202 | ENSRNOP00000038334 | Exonuclease 1. | MutL homolog 3 (E. coli) (Predicted), isoform CRA_a. | 0.817 |
Exo1 | Msh2 | ENSRNOP00000073202 | ENSRNOP00000021538 | Exonuclease 1. | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.976 |
Exo1 | Msh3 | ENSRNOP00000073202 | ENSRNOP00000018449 | Exonuclease 1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.930 |
Exo1 | Msh6 | ENSRNOP00000073202 | ENSRNOP00000021923 | Exonuclease 1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.979 |
Exo1 | Pcna | ENSRNOP00000073202 | ENSRNOP00000028887 | Exonuclease 1. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.934 |
Exo1 | Pms1 | ENSRNOP00000073202 | ENSRNOP00000047584 | Exonuclease 1. | PMS1 homolog 1, mismatch repair system component. | 0.838 |
Exo1 | Pms2 | ENSRNOP00000073202 | ENSRNOP00000069740 | Exonuclease 1. | PMS1 homolog 2, mismatch repair system component. | 0.980 |
Fancm | Exo1 | ENSRNOP00000074177 | ENSRNOP00000073202 | FA complementation group M. | Exonuclease 1. | 0.833 |
Fancm | Mlh1 | ENSRNOP00000074177 | ENSRNOP00000072285 | FA complementation group M. | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | 0.680 |
Fancm | Mlh3 | ENSRNOP00000074177 | ENSRNOP00000038334 | FA complementation group M. | MutL homolog 3 (E. coli) (Predicted), isoform CRA_a. | 0.570 |
Fancm | Msh2 | ENSRNOP00000074177 | ENSRNOP00000021538 | FA complementation group M. | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.790 |
Fancm | Msh3 | ENSRNOP00000074177 | ENSRNOP00000018449 | FA complementation group M. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.838 |
Fancm | Msh6 | ENSRNOP00000074177 | ENSRNOP00000021923 | FA complementation group M. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.872 |
Fancm | Pcna | ENSRNOP00000074177 | ENSRNOP00000028887 | FA complementation group M. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.947 |
Fancm | Pms1 | ENSRNOP00000074177 | ENSRNOP00000047584 | FA complementation group M. | PMS1 homolog 1, mismatch repair system component. | 0.523 |
Fancm | Pms2 | ENSRNOP00000074177 | ENSRNOP00000069740 | FA complementation group M. | PMS1 homolog 2, mismatch repair system component. | 0.550 |
Mlh1 | Exo1 | ENSRNOP00000072285 | ENSRNOP00000073202 | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | Exonuclease 1. | 0.968 |
Mlh1 | Fancm | ENSRNOP00000072285 | ENSRNOP00000074177 | DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] | FA complementation group M. | 0.680 |