STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defa5Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. (94 aa)    
Predicted Functional Partners:
Reg3g
Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...]
   
 
 0.614
Np4
Neutrophil antibiotic peptide NP-4.
   
 
0.610
Ctsg
Cathepsin G.
   
 
 0.594
Defb1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.
     
 0.589
Mcpt8
Mast cell protease 8; Belongs to the peptidase S1 family. Granzyme subfamily.
   
 
 0.584
RatNP-3b
Neutrophil antibiotic peptide NP-3B; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus; Belongs to the alpha-defensin family.
   
 
0.578
Elane
Elastase 2, neutrophil (Predicted); Belongs to the peptidase S1 family.
   
 
 0.560
Defb17
Beta-defensin 17; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.549
Camp
Cathelicidin antimicrobial peptide.
   
  
 0.547
F1LZJ7_RAT
Takusan domain-containing protein.
      
 0.539
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: medium (44%) [HD]