node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asic3 | Gpr132 | ENSRNOP00000011300 | ENSRNOP00000018613 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.554 |
Asic3 | Gpr4 | ENSRNOP00000011300 | ENSRNOP00000021894 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.524 |
Asic3 | Gpr65 | ENSRNOP00000011300 | ENSRNOP00000005055 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | T cell death associated protein 8; Belongs to the G-protein coupled receptor 1 family. | 0.656 |
Asic3 | LOC102553138 | ENSRNOP00000011300 | ENSRNOP00000064586 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. | 0.547 |
Cysltr1 | Cysltr2 | ENSRNOP00000075854 | ENSRNOP00000020187 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.950 |
Cysltr1 | Gpr132 | ENSRNOP00000075854 | ENSRNOP00000018613 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.501 |
Cysltr1 | Gpr4 | ENSRNOP00000075854 | ENSRNOP00000021894 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.526 |
Cysltr1 | Gpr65 | ENSRNOP00000075854 | ENSRNOP00000005055 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | T cell death associated protein 8; Belongs to the G-protein coupled receptor 1 family. | 0.519 |
Cysltr1 | LOC102553138 | ENSRNOP00000075854 | ENSRNOP00000064586 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. | 0.510 |
Cysltr2 | Cysltr1 | ENSRNOP00000020187 | ENSRNOP00000075854 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.950 |
Cysltr2 | Gpr132 | ENSRNOP00000020187 | ENSRNOP00000018613 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.534 |
Cysltr2 | Gpr4 | ENSRNOP00000020187 | ENSRNOP00000021894 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.510 |
Cysltr2 | Gpr65 | ENSRNOP00000020187 | ENSRNOP00000005055 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | T cell death associated protein 8; Belongs to the G-protein coupled receptor 1 family. | 0.519 |
Cysltr2 | LOC102553138 | ENSRNOP00000020187 | ENSRNOP00000064586 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. | 0.499 |
D3ZXT7_RAT | Gpr132 | ENSRNOP00000056204 | ENSRNOP00000018613 | Ig-like domain-containing protein. | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.486 |
Gpbar1 | Gpr132 | ENSRNOP00000075574 | ENSRNOP00000018613 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.489 |
Gpbar1 | Gpr142 | ENSRNOP00000075574 | ENSRNOP00000036358 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | G protein-coupled receptor 142; Belongs to the G-protein coupled receptor 1 family. | 0.699 |
Gpr132 | Asic3 | ENSRNOP00000018613 | ENSRNOP00000011300 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | 0.554 |
Gpr132 | Cysltr1 | ENSRNOP00000018613 | ENSRNOP00000075854 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.501 |
Gpr132 | Cysltr2 | ENSRNOP00000018613 | ENSRNOP00000020187 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.534 |