node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdh2 | Dsg2 | ENSRNOP00000021170 | ENSRNOP00000022270 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | Desmoglein 2. | 0.516 |
Cdh2 | Dsp | ENSRNOP00000021170 | ENSRNOP00000018649 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | Desmoplakin. | 0.823 |
Cdh2 | Jup | ENSRNOP00000021170 | ENSRNOP00000070840 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.981 |
Cdh2 | Tjp1 | ENSRNOP00000021170 | ENSRNOP00000072324 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.894 |
Dsc1 | Dsg1 | ENSRNOP00000075307 | ENSRNOP00000058060 | Desmocollin 1. | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.928 |
Dsc1 | Dsg2 | ENSRNOP00000075307 | ENSRNOP00000022270 | Desmocollin 1. | Desmoglein 2. | 0.810 |
Dsc1 | Dsg3 | ENSRNOP00000075307 | ENSRNOP00000072153 | Desmocollin 1. | Desmoglein 3. | 0.854 |
Dsc1 | Dsp | ENSRNOP00000075307 | ENSRNOP00000018649 | Desmocollin 1. | Desmoplakin. | 0.853 |
Dsc1 | Jup | ENSRNOP00000075307 | ENSRNOP00000070840 | Desmocollin 1. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.912 |
Dsc1 | Pkp1 | ENSRNOP00000075307 | ENSRNOP00000013532 | Desmocollin 1. | Plakophilin 1 (Predicted). | 0.756 |
Dsc1 | Pkp3 | ENSRNOP00000075307 | ENSRNOP00000020864 | Desmocollin 1. | Plakophilin 3 (Predicted), isoform CRA_a. | 0.824 |
Dsc2 | Dsg1 | ENSRNOP00000058135 | ENSRNOP00000058060 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.729 |
Dsc2 | Dsg2 | ENSRNOP00000058135 | ENSRNOP00000022270 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmoglein 2. | 0.999 |
Dsc2 | Dsg3 | ENSRNOP00000058135 | ENSRNOP00000072153 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmoglein 3. | 0.795 |
Dsc2 | Dsp | ENSRNOP00000058135 | ENSRNOP00000018649 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmoplakin. | 0.991 |
Dsc2 | Jup | ENSRNOP00000058135 | ENSRNOP00000070840 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.978 |
Dsc2 | Pkp1 | ENSRNOP00000058135 | ENSRNOP00000013532 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Plakophilin 1 (Predicted). | 0.825 |
Dsc2 | Pkp3 | ENSRNOP00000058135 | ENSRNOP00000020864 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Plakophilin 3 (Predicted), isoform CRA_a. | 0.876 |
Dsc2 | Tjp1 | ENSRNOP00000058135 | ENSRNOP00000072324 | Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Tight junction protein ZO-1; TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role [...] | 0.485 |
Dsg1 | Dsc1 | ENSRNOP00000058060 | ENSRNOP00000075307 | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmocollin 1. | 0.928 |