node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccz1b | Tgfbrap1 | ENSRNOP00000001365 | ENSRNOP00000069317 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Transforming growth factor, beta receptor-associated protein 1. | 0.891 |
Ccz1b | Vps11 | ENSRNOP00000001365 | ENSRNOP00000061998 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.975 |
Ccz1b | Vps16 | ENSRNOP00000001365 | ENSRNOP00000028821 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.981 |
Ccz1b | Vps18 | ENSRNOP00000001365 | ENSRNOP00000018717 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | VPS18 core subunit of CORVET and HOPS complexes. | 0.977 |
Ccz1b | Vps33a | ENSRNOP00000001365 | ENSRNOP00000073489 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.886 |
Ccz1b | Vps33b | ENSRNOP00000001365 | ENSRNOP00000017862 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesi [...] | 0.876 |
Ccz1b | Vps39 | ENSRNOP00000001365 | ENSRNOP00000075259 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | VPS39 subunit of HOPS complex. | 0.986 |
Ccz1b | Vps41 | ENSRNOP00000001365 | ENSRNOP00000063448 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. | 0.966 |
Ccz1b | Vps8 | ENSRNOP00000001365 | ENSRNOP00000030100 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | VPS8 subunit of CORVET complex. | 0.787 |
Ccz1b | Vti1a | ENSRNOP00000001365 | ENSRNOP00000058953 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2 (By similarity). May be concerned with increased secretion of cytokines as [...] | 0.723 |
Tgfbrap1 | Ccz1b | ENSRNOP00000069317 | ENSRNOP00000001365 | Transforming growth factor, beta receptor-associated protein 1. | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | 0.891 |
Tgfbrap1 | Vps11 | ENSRNOP00000069317 | ENSRNOP00000061998 | Transforming growth factor, beta receptor-associated protein 1. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.994 |
Tgfbrap1 | Vps16 | ENSRNOP00000069317 | ENSRNOP00000028821 | Transforming growth factor, beta receptor-associated protein 1. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.996 |
Tgfbrap1 | Vps18 | ENSRNOP00000069317 | ENSRNOP00000018717 | Transforming growth factor, beta receptor-associated protein 1. | VPS18 core subunit of CORVET and HOPS complexes. | 0.994 |
Tgfbrap1 | Vps33a | ENSRNOP00000069317 | ENSRNOP00000073489 | Transforming growth factor, beta receptor-associated protein 1. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.971 |
Tgfbrap1 | Vps33b | ENSRNOP00000069317 | ENSRNOP00000017862 | Transforming growth factor, beta receptor-associated protein 1. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesi [...] | 0.941 |
Tgfbrap1 | Vps39 | ENSRNOP00000069317 | ENSRNOP00000075259 | Transforming growth factor, beta receptor-associated protein 1. | VPS39 subunit of HOPS complex. | 0.973 |
Tgfbrap1 | Vps41 | ENSRNOP00000069317 | ENSRNOP00000063448 | Transforming growth factor, beta receptor-associated protein 1. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. | 0.973 |
Tgfbrap1 | Vps8 | ENSRNOP00000069317 | ENSRNOP00000030100 | Transforming growth factor, beta receptor-associated protein 1. | VPS8 subunit of CORVET complex. | 0.990 |
Tgfbrap1 | Vti1a | ENSRNOP00000069317 | ENSRNOP00000058953 | Transforming growth factor, beta receptor-associated protein 1. | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2 (By similarity). May be concerned with increased secretion of cytokines as [...] | 0.656 |