node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ap1s2 | Rap2b | ENSRNOP00000063764 | ENSRNOP00000019340 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). | 0.615 |
Arxes2-2 | Dnajc27 | ENSRNOP00000066197 | ENSRNOP00000073490 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.438 |
Arxes2-2 | Mrpl46 | ENSRNOP00000066197 | ENSRNOP00000061438 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | 39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.510 |
Arxes2-2 | Ranbp6 | ENSRNOP00000066197 | ENSRNOP00000074790 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | RAN-binding protein 6. | 0.571 |
Arxes2-2 | Rap2b | ENSRNOP00000066197 | ENSRNOP00000019340 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). | 0.513 |
Arxes2-2 | Spcs3 | ENSRNOP00000066197 | ENSRNOP00000062708 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | Signal peptidase complex subunit 3. | 0.544 |
Arxes2-2 | Tbc1d13 | ENSRNOP00000066197 | ENSRNOP00000021431 | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | TBC1 domain family, member 13. | 0.569 |
Dnajc27 | Arxes2-2 | ENSRNOP00000073490 | ENSRNOP00000066197 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Similar to Microsomal signal peptidase 23 kDa subunit (SPase 22 kDa subunit) (SPC22/23). | 0.438 |
Dnajc27 | Itsn1 | ENSRNOP00000073490 | ENSRNOP00000044773 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.590 |
Dnajc27 | Itsn2 | ENSRNOP00000073490 | ENSRNOP00000065329 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Intersectin 2. | 0.665 |
Dnajc27 | Mrpl46 | ENSRNOP00000073490 | ENSRNOP00000061438 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.539 |
Dnajc27 | Ranbp6 | ENSRNOP00000073490 | ENSRNOP00000074790 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | RAN-binding protein 6. | 0.520 |
Dnajc27 | Rap2b | ENSRNOP00000073490 | ENSRNOP00000019340 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). | 0.527 |
Dnajc27 | Spcs3 | ENSRNOP00000073490 | ENSRNOP00000062708 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Signal peptidase complex subunit 3. | 0.437 |
Dnajc27 | Tbc1d13 | ENSRNOP00000073490 | ENSRNOP00000021431 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | TBC1 domain family, member 13. | 0.490 |
Itsn1 | Dnajc27 | ENSRNOP00000044773 | ENSRNOP00000073490 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.590 |
Itsn1 | Itsn2 | ENSRNOP00000044773 | ENSRNOP00000065329 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | Intersectin 2. | 0.618 |
Itsn1 | Rap2b | ENSRNOP00000044773 | ENSRNOP00000019340 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). | 0.590 |
Itsn2 | Dnajc27 | ENSRNOP00000065329 | ENSRNOP00000073490 | Intersectin 2. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.665 |
Itsn2 | Itsn1 | ENSRNOP00000065329 | ENSRNOP00000044773 | Intersectin 2. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.618 |