node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adh4 | Cyp26a1 | ENSRNOP00000069857 | ENSRNOP00000022549 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.942 |
Adh4 | Dhrs3 | ENSRNOP00000069857 | ENSRNOP00000021155 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.417 |
Adh4 | Dhrs4 | ENSRNOP00000069857 | ENSRNOP00000024782 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.463 |
Adh4 | Lrat | ENSRNOP00000069857 | ENSRNOP00000035053 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodo [...] | 0.921 |
Adh4 | Rdh10 | ENSRNOP00000069857 | ENSRNOP00000009096 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. | 0.493 |
Adh4 | Rdh12 | ENSRNOP00000069857 | ENSRNOP00000074812 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.403 |
Adh4 | Retsat | ENSRNOP00000069857 | ENSRNOP00000019571 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.934 |
Cyp26a1 | Adh4 | ENSRNOP00000022549 | ENSRNOP00000069857 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.942 |
Cyp26a1 | Dhrs3 | ENSRNOP00000022549 | ENSRNOP00000021155 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.972 |
Cyp26a1 | Dhrs4 | ENSRNOP00000022549 | ENSRNOP00000024782 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.935 |
Cyp26a1 | Lrat | ENSRNOP00000022549 | ENSRNOP00000035053 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chromophore for rhodo [...] | 0.975 |
Cyp26a1 | Rdh10 | ENSRNOP00000022549 | ENSRNOP00000009096 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. | 0.978 |
Cyp26a1 | Rdh12 | ENSRNOP00000022549 | ENSRNOP00000074812 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.951 |
Cyp26a1 | Rdh16 | ENSRNOP00000022549 | ENSRNOP00000039311 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3- alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.942 |
Cyp26a1 | Rdh7 | ENSRNOP00000022549 | ENSRNOP00000005875 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.931 |
Cyp26a1 | Rdh8 | ENSRNOP00000022549 | ENSRNOP00000033991 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.936 |
Cyp26a1 | Retsat | ENSRNOP00000022549 | ENSRNOP00000019571 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.930 |
Dhrs3 | Adh4 | ENSRNOP00000021155 | ENSRNOP00000069857 | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.417 |
Dhrs3 | Cyp26a1 | ENSRNOP00000021155 | ENSRNOP00000022549 | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.972 |
Dhrs3 | Dhrs4 | ENSRNOP00000021155 | ENSRNOP00000024782 | Dehydrogenase/reductase (SDR family) member 3, isoform CRA_b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.932 |