node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dis3 | Rexo5 | ENSRNOP00000029411 | ENSRNOP00000073863 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. | RNA exonuclease 5. | 0.504 |
Dis3 | Tbl3 | ENSRNOP00000029411 | ENSRNOP00000018405 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. | Transducin beta-like protein 3. | 0.565 |
Mroh7 | Rexo2 | ENSRNOP00000072770 | ENSRNOP00000071290 | Maestro heat-like repeat-containing protein family member 7. | Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role for cellular nucleotide recycling (By similarity); Belongs to the oligoribonuclease family. | 0.631 |
Mroh7 | Rexo5 | ENSRNOP00000072770 | ENSRNOP00000073863 | Maestro heat-like repeat-containing protein family member 7. | RNA exonuclease 5. | 0.563 |
Pan3 | Rexo1 | ENSRNOP00000040388 | ENSRNOP00000024080 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | RNA exonuclease 1 homolog. | 0.615 |
Pan3 | Rexo1l1-ps1 | ENSRNOP00000040388 | ENSRNOP00000069746 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.604 |
Pan3 | Rexo5 | ENSRNOP00000040388 | ENSRNOP00000073863 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | RNA exonuclease 5. | 0.604 |
Pcna | Rexo1 | ENSRNOP00000028887 | ENSRNOP00000024080 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | RNA exonuclease 1 homolog. | 0.686 |
Pcna | Rexo1l1-ps1 | ENSRNOP00000028887 | ENSRNOP00000069746 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.686 |
Pcna | Rexo5 | ENSRNOP00000028887 | ENSRNOP00000073863 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | RNA exonuclease 5. | 0.686 |
Pinx1 | Rexo5 | ENSRNOP00000016027 | ENSRNOP00000073863 | PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). | RNA exonuclease 5. | 0.571 |
Pinx1 | Rpf2 | ENSRNOP00000016027 | ENSRNOP00000000717 | PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). | Ribosome production factor 2 homolog. | 0.565 |
Pinx1 | Tbl3 | ENSRNOP00000016027 | ENSRNOP00000018405 | PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). | Transducin beta-like protein 3. | 0.675 |
Rexo1 | Pan3 | ENSRNOP00000024080 | ENSRNOP00000040388 | RNA exonuclease 1 homolog. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | 0.615 |
Rexo1 | Pcna | ENSRNOP00000024080 | ENSRNOP00000028887 | RNA exonuclease 1 homolog. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.686 |
Rexo1 | Rexo1l1-ps1 | ENSRNOP00000024080 | ENSRNOP00000069746 | RNA exonuclease 1 homolog. | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | 0.902 |
Rexo1 | Rexo2 | ENSRNOP00000024080 | ENSRNOP00000071290 | RNA exonuclease 1 homolog. | Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role for cellular nucleotide recycling (By similarity); Belongs to the oligoribonuclease family. | 0.933 |
Rexo1 | Rexo5 | ENSRNOP00000024080 | ENSRNOP00000073863 | RNA exonuclease 1 homolog. | RNA exonuclease 5. | 0.904 |
Rexo1l1-ps1 | Pan3 | ENSRNOP00000069746 | ENSRNOP00000040388 | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | 0.604 |
Rexo1l1-ps1 | Pcna | ENSRNOP00000069746 | ENSRNOP00000028887 | REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.686 |