node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asf1a | Asf1b | ENSRNOP00000000471 | ENSRNOP00000006964 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | 0.629 |
Asf1a | Mcm2 | ENSRNOP00000000471 | ENSRNOP00000022231 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | DNA helicase; Belongs to the MCM family. | 0.908 |
Asf1a | Mcm5 | ENSRNOP00000000471 | ENSRNOP00000070472 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | DNA helicase; Belongs to the MCM family. | 0.514 |
Asf1a | Mcm6 | ENSRNOP00000000471 | ENSRNOP00000004969 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.630 |
Asf1a | Mms22l | ENSRNOP00000000471 | ENSRNOP00000009545 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | MMS22-like, DNA repair protein. | 0.498 |
Asf1a | Smarcal1 | ENSRNOP00000000471 | ENSRNOP00000022459 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] | 0.447 |
Asf1a | Ssrp1 | ENSRNOP00000000471 | ENSRNOP00000012022 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.423 |
Asf1a | Tonsl | ENSRNOP00000000471 | ENSRNOP00000019754 | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family. | 0.659 |
Asf1b | Asf1a | ENSRNOP00000006964 | ENSRNOP00000000471 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | 0.629 |
Asf1b | Mcm2 | ENSRNOP00000006964 | ENSRNOP00000022231 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | DNA helicase; Belongs to the MCM family. | 0.917 |
Asf1b | Mcm5 | ENSRNOP00000006964 | ENSRNOP00000070472 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | DNA helicase; Belongs to the MCM family. | 0.678 |
Asf1b | Mcm6 | ENSRNOP00000006964 | ENSRNOP00000004969 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.795 |
Asf1b | Mms22l | ENSRNOP00000006964 | ENSRNOP00000009545 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | MMS22-like, DNA repair protein. | 0.701 |
Asf1b | Smarcal1 | ENSRNOP00000006964 | ENSRNOP00000022459 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] | 0.495 |
Asf1b | Ssrp1 | ENSRNOP00000006964 | ENSRNOP00000012022 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.437 |
Asf1b | Tonsl | ENSRNOP00000006964 | ENSRNOP00000019754 | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted). | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family. | 0.658 |
Cenpi | Mcm5 | ENSRNOP00000041317 | ENSRNOP00000070472 | Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone (By similarity); Belongs to the CENP-I/CTF3 family. | DNA helicase; Belongs to the MCM family. | 0.588 |
Cenpi | Tonsl | ENSRNOP00000041317 | ENSRNOP00000019754 | Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone (By similarity); Belongs to the CENP-I/CTF3 family. | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family. | 0.568 |
Fbxl6 | Tonsl | ENSRNOP00000035719 | ENSRNOP00000019754 | F-box and leucine-rich repeat protein 6, isoform CRA_b. | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family. | 0.590 |
Mcm2 | Asf1a | ENSRNOP00000022231 | ENSRNOP00000000471 | DNA helicase; Belongs to the MCM family. | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (Predicted), isoform CRA_a. | 0.908 |