node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Glis3 | Hhex | ENSRNOP00000019816 | ENSRNOP00000022384 | GLIS family zinc finger 3. | Hematopoietically-expressed homeobox. | 0.648 |
Glis3 | Mnx1 | ENSRNOP00000019816 | ENSRNOP00000064986 | GLIS family zinc finger 3. | Motor neuron and pancreas homeobox 1. | 0.555 |
Glis3 | Neurod1 | ENSRNOP00000019816 | ENSRNOP00000007662 | GLIS family zinc finger 3. | Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | 0.540 |
Glis3 | Neurog3 | ENSRNOP00000019816 | ENSRNOP00000000661 | GLIS family zinc finger 3. | Neurogenin 3. | 0.564 |
Glis3 | Ptf1a | ENSRNOP00000019816 | ENSRNOP00000022727 | GLIS family zinc finger 3. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.540 |
Glis3 | Rfx6 | ENSRNOP00000019816 | ENSRNOP00000029306 | GLIS family zinc finger 3. | Regulatory factor X domain containing 1 (Predicted), isoform CRA_a. | 0.622 |
Glis3 | Slc30a8 | ENSRNOP00000019816 | ENSRNOP00000069455 | GLIS family zinc finger 3. | Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter (By similarity). May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.612 |
Glis3 | Stk36 | ENSRNOP00000019816 | ENSRNOP00000022839 | GLIS family zinc finger 3. | Serine/threonine kinase 36. | 0.538 |
Glis3 | Sufu | ENSRNOP00000019816 | ENSRNOP00000026987 | GLIS family zinc finger 3. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.706 |
Glis3 | Tcf7l2 | ENSRNOP00000019816 | ENSRNOP00000019681 | GLIS family zinc finger 3. | Transcription factor 7-like 2. | 0.538 |
Hhex | Glis3 | ENSRNOP00000022384 | ENSRNOP00000019816 | Hematopoietically-expressed homeobox. | GLIS family zinc finger 3. | 0.648 |
Hhex | Neurog3 | ENSRNOP00000022384 | ENSRNOP00000000661 | Hematopoietically-expressed homeobox. | Neurogenin 3. | 0.416 |
Hhex | Ptf1a | ENSRNOP00000022384 | ENSRNOP00000022727 | Hematopoietically-expressed homeobox. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.438 |
Hhex | Rfx6 | ENSRNOP00000022384 | ENSRNOP00000029306 | Hematopoietically-expressed homeobox. | Regulatory factor X domain containing 1 (Predicted), isoform CRA_a. | 0.590 |
Hhex | Slc30a8 | ENSRNOP00000022384 | ENSRNOP00000069455 | Hematopoietically-expressed homeobox. | Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter (By similarity). May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.768 |
Hhex | Tcf7l2 | ENSRNOP00000022384 | ENSRNOP00000019681 | Hematopoietically-expressed homeobox. | Transcription factor 7-like 2. | 0.717 |
Mnx1 | Glis3 | ENSRNOP00000064986 | ENSRNOP00000019816 | Motor neuron and pancreas homeobox 1. | GLIS family zinc finger 3. | 0.555 |
Mnx1 | Neurod1 | ENSRNOP00000064986 | ENSRNOP00000007662 | Motor neuron and pancreas homeobox 1. | Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | 0.652 |
Mnx1 | Neurog3 | ENSRNOP00000064986 | ENSRNOP00000000661 | Motor neuron and pancreas homeobox 1. | Neurogenin 3. | 0.658 |
Mnx1 | Ptf1a | ENSRNOP00000064986 | ENSRNOP00000022727 | Motor neuron and pancreas homeobox 1. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.694 |