Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apool | Homer3 | ENSRNOP00000005997 | ENSRNOP00000027428 | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity); Belongs to the Homer family. | 0.473 |
| Apool | Tmbim1 | ENSRNOP00000005997 | ENSRNOP00000019848 | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.670 |
| Ghitm | Tmbim1 | ENSRNOP00000018723 | ENSRNOP00000019848 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.569 |
| Ghitm | Tmbim6 | ENSRNOP00000018723 | ENSRNOP00000069944 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation; Belongs to the BI1 family. | 0.654 |
| Homer3 | Apool | ENSRNOP00000027428 | ENSRNOP00000005997 | Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity); Belongs to the Homer family. | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | 0.473 |
| Homer3 | Tmbim1 | ENSRNOP00000027428 | ENSRNOP00000019848 | Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity); Belongs to the Homer family. | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.442 |
| LOC100911917 | Med22 | ENSRNOP00000006720 | ENSRNOP00000062301 | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Mediator complex subunit 22. | 0.722 |
| LOC100911917 | Tmbim1 | ENSRNOP00000006720 | ENSRNOP00000019848 | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.522 |
| Mdm4 | Tmbim1 | ENSRNOP00000012984 | ENSRNOP00000019848 | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.406 |
| Med22 | LOC100911917 | ENSRNOP00000062301 | ENSRNOP00000006720 | Mediator complex subunit 22. | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.722 |
| Med22 | Tmbim1 | ENSRNOP00000062301 | ENSRNOP00000019848 | Mediator complex subunit 22. | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.522 |
| Oxnad1 | Tmbim1 | ENSRNOP00000026751 | ENSRNOP00000019848 | Oxidoreductase NAD-binding domain containing 1 (Predicted), isoform CRA_b. | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | 0.578 |
| Oxnad1 | Txndc11 | ENSRNOP00000026751 | ENSRNOP00000003332 | Oxidoreductase NAD-binding domain containing 1 (Predicted), isoform CRA_b. | Thioredoxin domain-containing 11. | 0.610 |
| Tmbim1 | Apool | ENSRNOP00000019848 | ENSRNOP00000005997 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | 0.670 |
| Tmbim1 | Ghitm | ENSRNOP00000019848 | ENSRNOP00000018723 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | 0.569 |
| Tmbim1 | Homer3 | ENSRNOP00000019848 | ENSRNOP00000027428 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity); Belongs to the Homer family. | 0.442 |
| Tmbim1 | LOC100911917 | ENSRNOP00000019848 | ENSRNOP00000006720 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.522 |
| Tmbim1 | Mdm4 | ENSRNOP00000019848 | ENSRNOP00000012984 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). | 0.406 |
| Tmbim1 | Med22 | ENSRNOP00000019848 | ENSRNOP00000062301 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Mediator complex subunit 22. | 0.522 |
| Tmbim1 | Oxnad1 | ENSRNOP00000019848 | ENSRNOP00000026751 | Transmembrane BAX inhibitor motif containing 1, isoform CRA_a; Belongs to the BI1 family. | Oxidoreductase NAD-binding domain containing 1 (Predicted), isoform CRA_b. | 0.578 |
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