STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Plekhf1Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). (279 aa)    
Predicted Functional Partners:
Zadh2
Zinc-binding alcohol dehydrogenase, domain-containing 2.
   
  
 0.602
Arrdc2
Arrestin domain containing 2, isoform CRA_a.
   
  
 0.576
Wdr54
Similar to D3Mm3e (Predicted), isoform CRA_a.
   
  
 0.563
Wdr54-2
WD repeat-containing protein 54.
      
 0.563
Ccdc107
Coiled-coil domain-containing 107.
   
  
 0.541
Pdzd4
PDZ domain-containing 4.
      
 0.510
4930444P10Rik
RIKEN cDNA 4930444P10 gene.
      
 0.506
Klri1
Killer cell lectin-like receptor subfamily I member 1; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity.
      
 0.506
Magea9
Similar to melanoma antigen family A, 5, isoform CRA_a.
      
 0.503
Klri2
Killer cell lectin-like receptor subfamily I member 2; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity.
      
 0.499
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (16%) [HD]