node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chmp1a | Chmp2a | ENSRNOP00000021475 | ENSRNOP00000038229 | Charged multivesicular body protein 1A. | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | 0.989 |
Chmp1a | Chmp3 | ENSRNOP00000021475 | ENSRNOP00000010253 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.989 |
Chmp1a | Chmp5 | ENSRNOP00000021475 | ENSRNOP00000011907 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | 0.933 |
Chmp1a | Chmp6 | ENSRNOP00000021475 | ENSRNOP00000005379 | Charged multivesicular body protein 1A. | Chromatin modifying protein 6 (Predicted). | 0.901 |
Chmp1a | Chmp7 | ENSRNOP00000021475 | ENSRNOP00000023318 | Charged multivesicular body protein 1A. | CHMP family, member 7 (Predicted), isoform CRA_a. | 0.881 |
Chmp1a | Ist1 | ENSRNOP00000021475 | ENSRNOP00000020365 | Charged multivesicular body protein 1A. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.948 |
Chmp1a | RGD1566265 | ENSRNOP00000021475 | ENSRNOP00000003188 | Charged multivesicular body protein 1A. | Similar to RIKEN cDNA 2610002M06 (Predicted). | 0.955 |
Chmp1a | Spast | ENSRNOP00000021475 | ENSRNOP00000033763 | Charged multivesicular body protein 1A. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.508 |
Chmp1a | Vps4a | ENSRNOP00000021475 | ENSRNOP00000046690 | Charged multivesicular body protein 1A. | Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] | 0.984 |
Chmp1a | Vta1 | ENSRNOP00000021475 | ENSRNOP00000068514 | Charged multivesicular body protein 1A. | Similar to RIKEN cDNA 1110059P08. | 0.990 |
Chmp2a | Chmp1a | ENSRNOP00000038229 | ENSRNOP00000021475 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Charged multivesicular body protein 1A. | 0.989 |
Chmp2a | Chmp3 | ENSRNOP00000038229 | ENSRNOP00000010253 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.992 |
Chmp2a | Chmp5 | ENSRNOP00000038229 | ENSRNOP00000011907 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | 0.954 |
Chmp2a | Chmp6 | ENSRNOP00000038229 | ENSRNOP00000005379 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Chromatin modifying protein 6 (Predicted). | 0.984 |
Chmp2a | Chmp7 | ENSRNOP00000038229 | ENSRNOP00000023318 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | CHMP family, member 7 (Predicted), isoform CRA_a. | 0.947 |
Chmp2a | Ist1 | ENSRNOP00000038229 | ENSRNOP00000020365 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.944 |
Chmp2a | RGD1566265 | ENSRNOP00000038229 | ENSRNOP00000003188 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Similar to RIKEN cDNA 2610002M06 (Predicted). | 0.987 |
Chmp2a | Spast | ENSRNOP00000038229 | ENSRNOP00000033763 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.624 |
Chmp2a | Vps4a | ENSRNOP00000038229 | ENSRNOP00000046690 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] | 0.955 |
Chmp2a | Vta1 | ENSRNOP00000038229 | ENSRNOP00000068514 | Similar to RIKEN cDNA 1500016L11 (Predicted), isoform CRA_c. | Similar to RIKEN cDNA 1110059P08. | 0.899 |