node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adss | Ampd1 | ENSRNOP00000005961 | ENSRNOP00000025248 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 0.963 |
Adss | Aprt | ENSRNOP00000005961 | ENSRNOP00000061449 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.760 |
Adss | Atic | ENSRNOP00000005961 | ENSRNOP00000021105 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.996 |
Adss | Guk1 | ENSRNOP00000005961 | ENSRNOP00000003926 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Guanylate kinase 1, isoform CRA_a. | 0.443 |
Adss | Impdh1 | ENSRNOP00000005961 | ENSRNOP00000027173 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.983 |
Adss | Nt5c1a | ENSRNOP00000005961 | ENSRNOP00000020524 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'-nucleotidase, cytosolic IA (Predicted). | 0.947 |
Adss | Nt5c2 | ENSRNOP00000005961 | ENSRNOP00000027351 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'-nucleotidase, cytosolic II. | 0.907 |
Adss | Nt5c3a | ENSRNOP00000005961 | ENSRNOP00000071357 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. | 0.902 |
Adss | Nt5c3b | ENSRNOP00000005961 | ENSRNOP00000022430 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity); Belongs to the pyrimidine 5'-nucleotidase family. | 0.900 |
Adss | Nt5m | ENSRNOP00000005961 | ENSRNOP00000004448 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5',3'-nucleotidase, mitochondrial. | 0.900 |
Ampd1 | Adss | ENSRNOP00000025248 | ENSRNOP00000005961 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.963 |
Ampd1 | Aprt | ENSRNOP00000025248 | ENSRNOP00000061449 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.983 |
Ampd1 | Atic | ENSRNOP00000025248 | ENSRNOP00000021105 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.966 |
Ampd1 | Impdh1 | ENSRNOP00000025248 | ENSRNOP00000027173 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.964 |
Ampd1 | Nt5c1a | ENSRNOP00000025248 | ENSRNOP00000020524 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 5'-nucleotidase, cytosolic IA (Predicted). | 0.966 |
Ampd1 | Nt5c2 | ENSRNOP00000025248 | ENSRNOP00000027351 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 5'-nucleotidase, cytosolic II. | 0.938 |
Ampd1 | Nt5c3a | ENSRNOP00000025248 | ENSRNOP00000071357 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. | 0.924 |
Ampd1 | Nt5c3b | ENSRNOP00000025248 | ENSRNOP00000022430 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity); Belongs to the pyrimidine 5'-nucleotidase family. | 0.909 |
Ampd1 | Nt5m | ENSRNOP00000025248 | ENSRNOP00000004448 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism. | 5',3'-nucleotidase, mitochondrial. | 0.943 |
Aprt | Adss | ENSRNOP00000061449 | ENSRNOP00000005961 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.760 |