node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acnat1 | Acnat2 | ENSRNOP00000072246 | ENSRNOP00000069269 | Acyl-coenzyme A amino acid N-acyltransferase 1. | Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Belongs to the C/M/P thioester hydrolase family. | 0.901 |
Acnat1 | Acot8 | ENSRNOP00000072246 | ENSRNOP00000020740 | Acyl-coenzyme A amino acid N-acyltransferase 1. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.913 |
Acnat1 | Baat | ENSRNOP00000072246 | ENSRNOP00000009777 | Acyl-coenzyme A amino acid N-acyltransferase 1. | Bile acid-CoA:amino acid N-acyltransferase; Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More efficient at taurine conjugation of cholyl CoA than glycine conjugation. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitate [...] | 0.904 |
Acnat1 | Slc27a5 | ENSRNOP00000072246 | ENSRNOP00000026574 | Acyl-coenzyme A amino acid N-acyltransferase 1. | Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Catalyzes the activation of the primary bile acid, chenodeoxycholic acid. Both primary bile acid (cholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (By similarity). In [...] | 0.963 |
Acnat2 | Acnat1 | ENSRNOP00000069269 | ENSRNOP00000072246 | Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-coenzyme A amino acid N-acyltransferase 1. | 0.901 |
Acnat2 | Acot8 | ENSRNOP00000069269 | ENSRNOP00000020740 | Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.913 |
Acnat2 | Baat | ENSRNOP00000069269 | ENSRNOP00000009777 | Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Belongs to the C/M/P thioester hydrolase family. | Bile acid-CoA:amino acid N-acyltransferase; Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More efficient at taurine conjugation of cholyl CoA than glycine conjugation. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitate [...] | 0.904 |
Acnat2 | Slc27a5 | ENSRNOP00000069269 | ENSRNOP00000026574 | Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Belongs to the C/M/P thioester hydrolase family. | Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Catalyzes the activation of the primary bile acid, chenodeoxycholic acid. Both primary bile acid (cholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (By similarity). In [...] | 0.961 |
Acot13 | Acot2 | ENSRNOP00000024878 | ENSRNOP00000013515 | Thioesterase superfamily member 2 (Predicted). | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | 0.711 |
Acot13 | Acot3 | ENSRNOP00000024878 | ENSRNOP00000073103 | Thioesterase superfamily member 2 (Predicted). | Acyl-CoA thioesterase 3. | 0.797 |
Acot13 | Acot5 | ENSRNOP00000024878 | ENSRNOP00000013760 | Thioesterase superfamily member 2 (Predicted). | Acyl-CoA thioesterase 5. | 0.653 |
Acot13 | Acot8 | ENSRNOP00000024878 | ENSRNOP00000020740 | Thioesterase superfamily member 2 (Predicted). | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.830 |
Acot13 | Acot9 | ENSRNOP00000024878 | ENSRNOP00000005033 | Thioesterase superfamily member 2 (Predicted). | Similar to acyl-CoA thioesterase, isoform CRA_b. | 0.784 |
Acot2 | Acot13 | ENSRNOP00000013515 | ENSRNOP00000024878 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Thioesterase superfamily member 2 (Predicted). | 0.711 |
Acot2 | Acot3 | ENSRNOP00000013515 | ENSRNOP00000073103 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-CoA thioesterase 3. | 0.902 |
Acot2 | Acot5 | ENSRNOP00000013515 | ENSRNOP00000013760 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-CoA thioesterase 5. | 0.902 |
Acot2 | Acot8 | ENSRNOP00000013515 | ENSRNOP00000020740 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.803 |
Acot2 | Acot9 | ENSRNOP00000013515 | ENSRNOP00000005033 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Similar to acyl-CoA thioesterase, isoform CRA_b. | 0.796 |
Acot2 | Baat | ENSRNOP00000013515 | ENSRNOP00000009777 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). Belongs to the C/M/P thioester hydrolase family. | Bile acid-CoA:amino acid N-acyltransferase; Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More efficient at taurine conjugation of cholyl CoA than glycine conjugation. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitate [...] | 0.437 |
Acot3 | Acot13 | ENSRNOP00000073103 | ENSRNOP00000024878 | Acyl-CoA thioesterase 3. | Thioesterase superfamily member 2 (Predicted). | 0.797 |