node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bag3 | Dnaja4 | ENSRNOP00000027616 | ENSRNOP00000017053 | Bcl2-associated athanogene 3. | DnaJ heat shock protein family (Hsp40) member A4. | 0.498 |
Bag3 | Dnajb1 | ENSRNOP00000027616 | ENSRNOP00000032313 | Bcl2-associated athanogene 3. | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.758 |
Bag3 | Dnajb4 | ENSRNOP00000027616 | ENSRNOP00000075386 | Bcl2-associated athanogene 3. | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | 0.563 |
Bag3 | Dnajb6 | ENSRNOP00000027616 | ENSRNOP00000041883 | Bcl2-associated athanogene 3. | DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). | 0.796 |
Bag3 | Hsp90ab1 | ENSRNOP00000027616 | ENSRNOP00000026920 | Bcl2-associated athanogene 3. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.849 |
Bag3 | Hspa12a | ENSRNOP00000027616 | ENSRNOP00000024548 | Bcl2-associated athanogene 3. | Heat shock 70kDa protein 12A (Predicted), isoform CRA_a. | 0.729 |
Bag3 | Hspa14 | ENSRNOP00000027616 | ENSRNOP00000020854 | Bcl2-associated athanogene 3. | Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). | 0.773 |
Bag3 | Hspa4 | ENSRNOP00000027616 | ENSRNOP00000023628 | Bcl2-associated athanogene 3. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.998 |
Dnaja2 | Dnaja4 | ENSRNOP00000022573 | ENSRNOP00000017053 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ heat shock protein family (Hsp40) member A4. | 0.733 |
Dnaja2 | Dnajb1 | ENSRNOP00000022573 | ENSRNOP00000032313 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.817 |
Dnaja2 | Dnajb4 | ENSRNOP00000022573 | ENSRNOP00000075386 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | 0.687 |
Dnaja2 | Dnajb6 | ENSRNOP00000022573 | ENSRNOP00000041883 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). | 0.531 |
Dnaja2 | Dnajc2 | ENSRNOP00000022573 | ENSRNOP00000016909 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] | 0.483 |
Dnaja2 | Hsp90ab1 | ENSRNOP00000022573 | ENSRNOP00000026920 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.816 |
Dnaja2 | Hspa12a | ENSRNOP00000022573 | ENSRNOP00000024548 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70kDa protein 12A (Predicted), isoform CRA_a. | 0.542 |
Dnaja2 | Hspa14 | ENSRNOP00000022573 | ENSRNOP00000020854 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). | 0.805 |
Dnaja2 | Hspa4 | ENSRNOP00000022573 | ENSRNOP00000023628 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.804 |
Dnaja4 | Bag3 | ENSRNOP00000017053 | ENSRNOP00000027616 | DnaJ heat shock protein family (Hsp40) member A4. | Bcl2-associated athanogene 3. | 0.498 |
Dnaja4 | Dnaja2 | ENSRNOP00000017053 | ENSRNOP00000022573 | DnaJ heat shock protein family (Hsp40) member A4. | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.733 |
Dnaja4 | Dnajb1 | ENSRNOP00000017053 | ENSRNOP00000032313 | DnaJ heat shock protein family (Hsp40) member A4. | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.819 |