node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Il13 | Il13ra1 | ENSRNOP00000010121 | ENSRNOP00000017746 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin 13 receptor, alpha 1, isoform CRA_b. | 0.998 |
Il13 | Il13ra2 | ENSRNOP00000010121 | ENSRNOP00000069280 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13). | 0.999 |
Il13 | Il2rg | ENSRNOP00000010121 | ENSRNOP00000005343 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin 2 receptor, gamma (Severe combined immunodeficiency), isoform CRA_a. | 0.879 |
Il13 | Il4 | ENSRNOP00000010121 | ENSRNOP00000010029 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.976 |
Il13 | Il4r | ENSRNOP00000010121 | ENSRNOP00000020994 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.999 |
Il13 | Jak1 | ENSRNOP00000010121 | ENSRNOP00000061649 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Tyrosine-protein kinase. | 0.635 |
Il13 | Jak2 | ENSRNOP00000010121 | ENSRNOP00000071877 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.675 |
Il13 | Jak3 | ENSRNOP00000010121 | ENSRNOP00000025312 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.634 |
Il13 | LOC100360218 | ENSRNOP00000010121 | ENSRNOP00000070979 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin 13 receptor, alpha 1-like. | 0.987 |
Il13 | Stat6 | ENSRNOP00000010121 | ENSRNOP00000072301 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Signal transducer and activator of transcription. | 0.850 |
Il13ra1 | Il13 | ENSRNOP00000017746 | ENSRNOP00000010121 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.998 |
Il13ra1 | Il13ra2 | ENSRNOP00000017746 | ENSRNOP00000069280 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13). | 0.726 |
Il13ra1 | Il2rg | ENSRNOP00000017746 | ENSRNOP00000005343 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Interleukin 2 receptor, gamma (Severe combined immunodeficiency), isoform CRA_a. | 0.486 |
Il13ra1 | Il4 | ENSRNOP00000017746 | ENSRNOP00000010029 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.997 |
Il13ra1 | Il4r | ENSRNOP00000017746 | ENSRNOP00000020994 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.994 |
Il13ra1 | Jak1 | ENSRNOP00000017746 | ENSRNOP00000061649 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Tyrosine-protein kinase. | 0.934 |
Il13ra1 | Jak2 | ENSRNOP00000017746 | ENSRNOP00000071877 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.926 |
Il13ra1 | Jak3 | ENSRNOP00000017746 | ENSRNOP00000025312 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.866 |
Il13ra1 | Stat6 | ENSRNOP00000017746 | ENSRNOP00000072301 | Interleukin 13 receptor, alpha 1, isoform CRA_b. | Signal transducer and activator of transcription. | 0.855 |
Il13ra2 | Il13 | ENSRNOP00000069280 | ENSRNOP00000010121 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13). | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.999 |