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Ugcg protein (Rattus norvegicus) - STRING interaction network
"Ugcg" - Ceramide glucosyltransferase in Rattus norvegicus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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UgcgCeramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Able to use UDP-galactose to synthesize galactosylceramide with 10% of efficiency with which it utilizes UDP-glucose. May also serve as a "flippase" (394 aa)    
Predicted Functional Partners:
Cerk
Ceramide kinase (531 aa)
       
  0.980
Smpd2
Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (422 aa)
         
  0.976
Asah1
Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (394 aa)
         
  0.968
Cers2
Longevity assurance homolog 2 (S. cerevisiae); Ceramide synthase 2 (380 aa)
     
 
  0.966
Cers4
Longevity assurance homolog 4 (S. cerevisiae) (Predicted); Ceramide synthase 4 (393 aa)
     
 
  0.965
Cers6
Ceramide synthase 6 (282 aa)
     
 
  0.963
Smpd1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide (627 aa)
     
 
  0.961
Cers3
Ceramide synthase 3 (391 aa)
     
 
  0.960
Degs1
Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily (323 aa)
         
  0.960
Acer2
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (275 aa)
     
 
  0.959
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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