node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Grb2 | Ptpn14 | ENSRNOP00000005347 | ENSRNOP00000072308 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.552 |
Grb2 | Ptpra | ENSRNOP00000005347 | ENSRNOP00000069583 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | 0.929 |
Grb2 | Ptpre | ENSRNOP00000005347 | ENSRNOP00000021359 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | 0.591 |
Grb2 | Pts | ENSRNOP00000005347 | ENSRNOP00000012434 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.499 |
Grb2 | rCG_54231 | ENSRNOP00000005347 | ENSRNOP00000069605 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | RCG54231. | 0.544 |
Kcnb1 | Ptpre | ENSRNOP00000065961 | ENSRNOP00000021359 | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | 0.450 |
Ptpn14 | Grb2 | ENSRNOP00000072308 | ENSRNOP00000005347 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.552 |
Ptpn14 | Ptpra | ENSRNOP00000072308 | ENSRNOP00000069583 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | 0.531 |
Ptpn14 | Ptpre | ENSRNOP00000072308 | ENSRNOP00000021359 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | 0.543 |
Ptpn14 | Ptprg | ENSRNOP00000072308 | ENSRNOP00000039045 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Protein tyrosine phosphatase, receptor type, G. | 0.552 |
Ptpn14 | Ptprj | ENSRNOP00000072308 | ENSRNOP00000070464 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Protein tyrosine phosphatase, receptor type, J. | 0.489 |
Ptpn14 | Pts | ENSRNOP00000072308 | ENSRNOP00000012434 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.515 |
Ptpra | Grb2 | ENSRNOP00000069583 | ENSRNOP00000005347 | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.929 |
Ptpra | Ptpn14 | ENSRNOP00000069583 | ENSRNOP00000072308 | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.531 |
Ptpra | Ptpre | ENSRNOP00000069583 | ENSRNOP00000021359 | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | 0.546 |
Ptpra | Pts | ENSRNOP00000069583 | ENSRNOP00000012434 | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin; Belongs to the PTPS family. | 0.779 |
Ptpra | rCG_54231 | ENSRNOP00000069583 | ENSRNOP00000069605 | Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. | RCG54231. | 0.698 |
Ptpre | Grb2 | ENSRNOP00000021359 | ENSRNOP00000005347 | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.591 |
Ptpre | Kcnb1 | ENSRNOP00000021359 | ENSRNOP00000065961 | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] | 0.450 |
Ptpre | Ptpn14 | ENSRNOP00000021359 | ENSRNOP00000072308 | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.543 |