node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crk | Dock1 | ENSRNOP00000006407 | ENSRNOP00000051781 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | 0.995 |
Crk | Dock2 | ENSRNOP00000006407 | ENSRNOP00000056557 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Uncharacterized protein; Belongs to the DOCK family. | 0.848 |
Crk | Dock3 | ENSRNOP00000006407 | ENSRNOP00000019867 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Dedicator of cyto-kinesis 3; Belongs to the DOCK family. | 0.691 |
Crk | Dock4 | ENSRNOP00000006407 | ENSRNOP00000006709 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Dedicator of cytokinesis 4; Belongs to the DOCK family. | 0.615 |
Crk | Dock5 | ENSRNOP00000006407 | ENSRNOP00000055674 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Dedicator of cytokinesis 5; Belongs to the DOCK family. | 0.801 |
Crk | Elmo1 | ENSRNOP00000006407 | ENSRNOP00000073656 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Engulfment and cell motility 1 splice 1 variant. | 0.985 |
Crk | Elmo2 | ENSRNOP00000006407 | ENSRNOP00000039023 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | 0.966 |
Crk | Elmo3 | ENSRNOP00000006407 | ENSRNOP00000021362 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | 0.654 |
Crk | Gulp1 | ENSRNOP00000006407 | ENSRNOP00000004463 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity). | 0.701 |
Dock1 | Crk | ENSRNOP00000051781 | ENSRNOP00000006407 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | 0.995 |
Dock1 | Dock3 | ENSRNOP00000051781 | ENSRNOP00000019867 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Dedicator of cyto-kinesis 3; Belongs to the DOCK family. | 0.456 |
Dock1 | Dock4 | ENSRNOP00000051781 | ENSRNOP00000006709 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Dedicator of cytokinesis 4; Belongs to the DOCK family. | 0.549 |
Dock1 | Dock5 | ENSRNOP00000051781 | ENSRNOP00000055674 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Dedicator of cytokinesis 5; Belongs to the DOCK family. | 0.486 |
Dock1 | Elmo1 | ENSRNOP00000051781 | ENSRNOP00000073656 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility 1 splice 1 variant. | 0.998 |
Dock1 | Elmo2 | ENSRNOP00000051781 | ENSRNOP00000039023 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | 0.996 |
Dock1 | Elmo3 | ENSRNOP00000051781 | ENSRNOP00000021362 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | 0.969 |
Dock1 | Gulp1 | ENSRNOP00000051781 | ENSRNOP00000004463 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity). | 0.556 |
Dock1 | Rhog | ENSRNOP00000051781 | ENSRNOP00000027641 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Ras homolog gene family, member G (Rho G). | 0.984 |
Dock2 | Crk | ENSRNOP00000056557 | ENSRNOP00000006407 | Uncharacterized protein; Belongs to the DOCK family. | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | 0.848 |
Dock2 | Elmo1 | ENSRNOP00000056557 | ENSRNOP00000073656 | Uncharacterized protein; Belongs to the DOCK family. | Engulfment and cell motility 1 splice 1 variant. | 0.996 |