node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aasdh | Acaa1a | ENSRNOP00000002907 | ENSRNOP00000050691 | Aminoadipate-semialdehyde dehydrogenase. | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 0.443 |
Aasdh | Acox2 | ENSRNOP00000002907 | ENSRNOP00000010260 | Aminoadipate-semialdehyde dehydrogenase. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids. | 0.712 |
Aasdh | Acoxl | ENSRNOP00000002907 | ENSRNOP00000021740 | Aminoadipate-semialdehyde dehydrogenase. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.705 |
Aasdh | Eci2 | ENSRNOP00000002907 | ENSRNOP00000022022 | Aminoadipate-semialdehyde dehydrogenase. | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. | 0.608 |
Aasdh | Etfa | ENSRNOP00000002907 | ENSRNOP00000020544 | Aminoadipate-semialdehyde dehydrogenase. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.478 |
Aasdh | Fasn | ENSRNOP00000002907 | ENSRNOP00000064445 | Aminoadipate-semialdehyde dehydrogenase. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.975 |
Aasdh | Hsdl2 | ENSRNOP00000002907 | ENSRNOP00000056213 | Aminoadipate-semialdehyde dehydrogenase. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.651 |
Aasdh | Ppara | ENSRNOP00000002907 | ENSRNOP00000038651 | Aminoadipate-semialdehyde dehydrogenase. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.612 |
Acaa1a | Aasdh | ENSRNOP00000050691 | ENSRNOP00000002907 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Aminoadipate-semialdehyde dehydrogenase. | 0.443 |
Acaa1a | Acox2 | ENSRNOP00000050691 | ENSRNOP00000010260 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids. | 0.930 |
Acaa1a | Acoxl | ENSRNOP00000050691 | ENSRNOP00000021740 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.730 |
Acaa1a | Eci2 | ENSRNOP00000050691 | ENSRNOP00000022022 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. | 0.973 |
Acaa1a | Etfa | ENSRNOP00000050691 | ENSRNOP00000020544 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.673 |
Acaa1a | Etfb | ENSRNOP00000050691 | ENSRNOP00000024083 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role (By similarity). | 0.567 |
Acaa1a | Fasn | ENSRNOP00000050691 | ENSRNOP00000064445 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.540 |
Acaa1a | Hsd17b4 | ENSRNOP00000050691 | ENSRNOP00000070792 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.828 |
Acaa1a | Hsdl2 | ENSRNOP00000050691 | ENSRNOP00000056213 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.862 |
Acaa1a | Ppara | ENSRNOP00000050691 | ENSRNOP00000038651 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.512 |
Acox2 | Aasdh | ENSRNOP00000010260 | ENSRNOP00000002907 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids. | Aminoadipate-semialdehyde dehydrogenase. | 0.712 |
Acox2 | Acaa1a | ENSRNOP00000010260 | ENSRNOP00000050691 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids. | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 0.930 |