node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcb7 | Bola1 | ENSRNOP00000003739 | ENSRNOP00000028767 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | 0.564 |
Abcb7 | Ciao1 | ENSRNOP00000003739 | ENSRNOP00000017603 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | 0.543 |
Abcb7 | Ciao3 | ENSRNOP00000003739 | ENSRNOP00000026518 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity); Belongs to the NARF family. | 0.617 |
Abcb7 | Ciapin1 | ENSRNOP00000003739 | ENSRNOP00000021769 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.657 |
Abcb7 | Glrx3 | ENSRNOP00000003739 | ENSRNOP00000022406 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.599 |
Abcb7 | Lias | ENSRNOP00000003739 | ENSRNOP00000003779 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.537 |
Abcb7 | Mms19 | ENSRNOP00000003739 | ENSRNOP00000065140 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | MMS19 homolog, cytosolic iron-sulfur assembly component. | 0.711 |
Abcb7 | Ndor1 | ENSRNOP00000003739 | ENSRNOP00000014445 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.535 |
Bola1 | Abcb7 | ENSRNOP00000028767 | ENSRNOP00000003739 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. | 0.564 |
Bola1 | Bola2 | ENSRNOP00000028767 | ENSRNOP00000066485 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | BolA family member 2; Belongs to the BolA/IbaG family. | 0.979 |
Bola1 | Ciao3 | ENSRNOP00000028767 | ENSRNOP00000026518 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity); Belongs to the NARF family. | 0.513 |
Bola1 | Ciapin1 | ENSRNOP00000028767 | ENSRNOP00000021769 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.866 |
Bola1 | Glrx3 | ENSRNOP00000028767 | ENSRNOP00000022406 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.973 |
Bola1 | Lias | ENSRNOP00000028767 | ENSRNOP00000003779 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.728 |
Bola1 | Mms19 | ENSRNOP00000028767 | ENSRNOP00000065140 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | MMS19 homolog, cytosolic iron-sulfur assembly component. | 0.638 |
Bola2 | Bola1 | ENSRNOP00000066485 | ENSRNOP00000028767 | BolA family member 2; Belongs to the BolA/IbaG family. | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | 0.979 |
Bola2 | Ciao3 | ENSRNOP00000066485 | ENSRNOP00000026518 | BolA family member 2; Belongs to the BolA/IbaG family. | Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity); Belongs to the NARF family. | 0.574 |
Bola2 | Ciapin1 | ENSRNOP00000066485 | ENSRNOP00000021769 | BolA family member 2; Belongs to the BolA/IbaG family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.899 |
Bola2 | Glrx3 | ENSRNOP00000066485 | ENSRNOP00000022406 | BolA family member 2; Belongs to the BolA/IbaG family. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.996 |
Bola2 | Lias | ENSRNOP00000066485 | ENSRNOP00000003779 | BolA family member 2; Belongs to the BolA/IbaG family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.662 |