node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acadvl | Gpr4 | ENSRNOP00000024973 | ENSRNOP00000021894 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family. | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.634 |
Asic3 | Asic4 | ENSRNOP00000011300 | ENSRNOP00000027135 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. | 0.591 |
Asic3 | Gpr132 | ENSRNOP00000011300 | ENSRNOP00000018613 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.554 |
Asic3 | Gpr4 | ENSRNOP00000011300 | ENSRNOP00000021894 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.524 |
Asic4 | Asic3 | ENSRNOP00000027135 | ENSRNOP00000011300 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | 0.591 |
Asic4 | Gpr4 | ENSRNOP00000027135 | ENSRNOP00000021894 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.517 |
Cysltr1 | Cysltr2 | ENSRNOP00000075854 | ENSRNOP00000020187 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.950 |
Cysltr1 | Gpr132 | ENSRNOP00000075854 | ENSRNOP00000018613 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.501 |
Cysltr1 | Gpr4 | ENSRNOP00000075854 | ENSRNOP00000021894 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.526 |
Cysltr1 | Lpar1 | ENSRNOP00000075854 | ENSRNOP00000043652 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.548 |
Cysltr2 | Cysltr1 | ENSRNOP00000020187 | ENSRNOP00000075854 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.950 |
Cysltr2 | Gpr132 | ENSRNOP00000020187 | ENSRNOP00000018613 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | 0.534 |
Cysltr2 | Gpr4 | ENSRNOP00000020187 | ENSRNOP00000021894 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.510 |
Cysltr2 | Lpar1 | ENSRNOP00000020187 | ENSRNOP00000043652 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.524 |
Gpr132 | Asic3 | ENSRNOP00000018613 | ENSRNOP00000011300 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | 0.554 |
Gpr132 | Cysltr1 | ENSRNOP00000018613 | ENSRNOP00000075854 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.501 |
Gpr132 | Cysltr2 | ENSRNOP00000018613 | ENSRNOP00000020187 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). | 0.534 |
Gpr132 | Gpr4 | ENSRNOP00000018613 | ENSRNOP00000021894 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.655 |
Gpr132 | Lpar1 | ENSRNOP00000018613 | ENSRNOP00000043652 | G protein-coupled receptor 132; Belongs to the G-protein coupled receptor 1 family. | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.437 |
Gpr3 | Gpr4 | ENSRNOP00000068107 | ENSRNOP00000021894 | G-protein coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth. Maintains also meiotic arrest in oocytes (By similarity). | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. | 0.534 |