STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fam92aFamily with sequence similarity 92 member A. (355 aa)    
Predicted Functional Partners:
Cby1
Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.
   
 
 0.777
Dzip1l
Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.
   
 
 0.759
Ubtd2
Ubiquitin domain-containing 2.
   
  
 0.688
Txndc15
Thioredoxin domain-containing protein 15; Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis.
      
 0.683
Cage1
Cancer-associated gene 1 protein homolog.
   
  
 0.602
Endod1
Uncharacterized protein.
    
 
 0.596
C2cd2
Similar to RIKEN cDNA 5830404H04, isoform CRA_b.
      
 0.586
Slc5a10
Solute carrier family 5 member 10; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.543
D3ZDY6_RAT
CHCH domain-containing protein.
      
 0.526
Tm2d1
TM2 domain containing 1 (Predicted), isoform CRA_a.
   
  
 0.521
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.