node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc42bpb | Mamdc4 | ENSRNOP00000036487 | ENSRNOP00000022390 | Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and su [...] | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.520 |
Cdc42bpb | Usp54 | ENSRNOP00000036487 | ENSRNOP00000068778 | Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and su [...] | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.508 |
Cel | Mamdc4 | ENSRNOP00000014572 | ENSRNOP00000022390 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.491 |
Dop1b | Mamdc4 | ENSRNOP00000070233 | ENSRNOP00000022390 | DOP1 leucine zipper-like protein B. | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.570 |
Dop1b | Usp54 | ENSRNOP00000070233 | ENSRNOP00000068778 | DOP1 leucine zipper-like protein B. | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.570 |
LOC500354 | Mamdc4 | ENSRNOP00000033325 | ENSRNOP00000022390 | Uncharacterized protein C12orf60 homolog. | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.559 |
Mamdc4 | Cdc42bpb | ENSRNOP00000022390 | ENSRNOP00000036487 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and su [...] | 0.520 |
Mamdc4 | Cel | ENSRNOP00000022390 | ENSRNOP00000014572 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | 0.491 |
Mamdc4 | Dop1b | ENSRNOP00000022390 | ENSRNOP00000070233 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | DOP1 leucine zipper-like protein B. | 0.570 |
Mamdc4 | LOC500354 | ENSRNOP00000022390 | ENSRNOP00000033325 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Uncharacterized protein C12orf60 homolog. | 0.559 |
Mamdc4 | Pitpnm1 | ENSRNOP00000022390 | ENSRNOP00000025084 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.505 |
Mamdc4 | Srrm2 | ENSRNOP00000022390 | ENSRNOP00000072307 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Serine/arginine repetitive matrix 2. | 0.475 |
Mamdc4 | Tanc2 | ENSRNOP00000022390 | ENSRNOP00000075014 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. | 0.611 |
Mamdc4 | Tceanc2 | ENSRNOP00000022390 | ENSRNOP00000049524 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Transcription elongation factor A N-terminal and central domain-containing protein 2. | 0.626 |
Mamdc4 | Tmem252 | ENSRNOP00000022390 | ENSRNOP00000030850 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Transmembrane protein 252. | 0.697 |
Mamdc4 | Usp54 | ENSRNOP00000022390 | ENSRNOP00000068778 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.728 |
Pitpnm1 | Mamdc4 | ENSRNOP00000025084 | ENSRNOP00000022390 | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.505 |
Pitpnm1 | Usp54 | ENSRNOP00000025084 | ENSRNOP00000068778 | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.516 |
Srrm2 | Mamdc4 | ENSRNOP00000072307 | ENSRNOP00000022390 | Serine/arginine repetitive matrix 2. | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. | 0.475 |
Srrm2 | Usp54 | ENSRNOP00000072307 | ENSRNOP00000068778 | Serine/arginine repetitive matrix 2. | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.476 |