node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bola1 | Bola2 | ENSRNOP00000028767 | ENSRNOP00000066485 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | BolA family member 2; Belongs to the BolA/IbaG family. | 0.979 |
Bola1 | Bola3 | ENSRNOP00000028767 | ENSRNOP00000030813 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | 0.920 |
Bola1 | Ciapin1 | ENSRNOP00000028767 | ENSRNOP00000021769 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.866 |
Bola1 | Glrx3 | ENSRNOP00000028767 | ENSRNOP00000022406 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.973 |
Bola1 | Glrx5 | ENSRNOP00000028767 | ENSRNOP00000005781 | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | Glutaredoxin 5 homolog (S. cerevisiae) (Predicted), isoform CRA_b. | 0.966 |
Bola2 | Bola1 | ENSRNOP00000066485 | ENSRNOP00000028767 | BolA family member 2; Belongs to the BolA/IbaG family. | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | 0.979 |
Bola2 | Bola3 | ENSRNOP00000066485 | ENSRNOP00000030813 | BolA family member 2; Belongs to the BolA/IbaG family. | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | 0.735 |
Bola2 | Ciapin1 | ENSRNOP00000066485 | ENSRNOP00000021769 | BolA family member 2; Belongs to the BolA/IbaG family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.899 |
Bola2 | Glrx3 | ENSRNOP00000066485 | ENSRNOP00000022406 | BolA family member 2; Belongs to the BolA/IbaG family. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.996 |
Bola2 | Glrx5 | ENSRNOP00000066485 | ENSRNOP00000005781 | BolA family member 2; Belongs to the BolA/IbaG family. | Glutaredoxin 5 homolog (S. cerevisiae) (Predicted), isoform CRA_b. | 0.869 |
Bola3 | Bola1 | ENSRNOP00000030813 | ENSRNOP00000028767 | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | 0.920 |
Bola3 | Bola2 | ENSRNOP00000030813 | ENSRNOP00000066485 | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | BolA family member 2; Belongs to the BolA/IbaG family. | 0.735 |
Bola3 | Glrx3 | ENSRNOP00000030813 | ENSRNOP00000022406 | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.772 |
Bola3 | Glrx5 | ENSRNOP00000030813 | ENSRNOP00000005781 | Similar to BolA domain-containing protein like (11.4 kD) (1P25) (Predicted); Belongs to the BolA/IbaG family. | Glutaredoxin 5 homolog (S. cerevisiae) (Predicted), isoform CRA_b. | 0.857 |
Cacybp | Glrx3 | ENSRNOP00000003586 | ENSRNOP00000022406 | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.722 |
Cct4 | Cct8 | ENSRNOP00000012847 | ENSRNOP00000002169 | T-complex protein 1 subunit delta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | Chaperonin subunit 8 (Theta) (Predicted), isoform CRA_a. | 0.999 |
Cct4 | Glrx3 | ENSRNOP00000012847 | ENSRNOP00000022406 | T-complex protein 1 subunit delta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.864 |
Cct8 | Cct4 | ENSRNOP00000002169 | ENSRNOP00000012847 | Chaperonin subunit 8 (Theta) (Predicted), isoform CRA_a. | T-complex protein 1 subunit delta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | 0.999 |
Cct8 | Glrx3 | ENSRNOP00000002169 | ENSRNOP00000022406 | Chaperonin subunit 8 (Theta) (Predicted), isoform CRA_a. | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation (By similarity). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). ECO:0000250|UniProtKB:Q9CQM9. | 0.781 |
Ciapin1 | Bola1 | ENSRNOP00000021769 | ENSRNOP00000028767 | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | BolA-like 1 (E. coli) (Predicted); Belongs to the BolA/IbaG family. | 0.866 |