node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atl1 | Reep1 | ENSRNOP00000041993 | ENSRNOP00000061062 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.969 |
Atl1 | Reep2 | ENSRNOP00000041993 | ENSRNOP00000065717 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.831 |
Atl1 | Reep5 | ENSRNOP00000041993 | ENSRNOP00000027345 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors. | 0.625 |
Atl1 | Rtn2 | ENSRNOP00000041993 | ENSRNOP00000022528 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Reticulon. | 0.836 |
Atl1 | Spast | ENSRNOP00000041993 | ENSRNOP00000033763 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.948 |
Atl2 | Reep1 | ENSRNOP00000008988 | ENSRNOP00000061062 | Atlastin GTPase 2. | Receptor expression-enhancing protein. | 0.832 |
Atl2 | Reep2 | ENSRNOP00000008988 | ENSRNOP00000065717 | Atlastin GTPase 2. | Receptor expression-enhancing protein. | 0.664 |
Atl2 | Reep5 | ENSRNOP00000008988 | ENSRNOP00000027345 | Atlastin GTPase 2. | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors. | 0.608 |
Atl2 | Rtn2 | ENSRNOP00000008988 | ENSRNOP00000022528 | Atlastin GTPase 2. | Reticulon. | 0.758 |
Atl2 | Spast | ENSRNOP00000008988 | ENSRNOP00000033763 | Atlastin GTPase 2. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.839 |
Atl3 | Reep1 | ENSRNOP00000028787 | ENSRNOP00000061062 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.832 |
Atl3 | Reep2 | ENSRNOP00000028787 | ENSRNOP00000065717 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.672 |
Atl3 | Reep5 | ENSRNOP00000028787 | ENSRNOP00000027345 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors. | 0.602 |
Atl3 | Rtn2 | ENSRNOP00000028787 | ENSRNOP00000022528 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Reticulon. | 0.787 |
Atl3 | Spast | ENSRNOP00000028787 | ENSRNOP00000033763 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.812 |
Bace1 | Rtn2 | ENSRNOP00000022796 | ENSRNOP00000022528 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | Reticulon. | 0.931 |
Bace1 | Rtn4r | ENSRNOP00000022796 | ENSRNOP00000041517 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Requir [...] | 0.547 |
Reep1 | Atl1 | ENSRNOP00000061062 | ENSRNOP00000041993 | Receptor expression-enhancing protein. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.969 |
Reep1 | Atl2 | ENSRNOP00000061062 | ENSRNOP00000008988 | Receptor expression-enhancing protein. | Atlastin GTPase 2. | 0.832 |
Reep1 | Atl3 | ENSRNOP00000061062 | ENSRNOP00000028787 | Receptor expression-enhancing protein. | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.832 |