node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh18a1 | Aldh18a1-2 | ENSRNOP00000020940 | ENSRNOP00000074318 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Aldehyde dehydrogenase 18 family, member A1. | 0.999 |
Aldh18a1 | Arg1 | ENSRNOP00000020940 | ENSRNOP00000017911 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.555 |
Aldh18a1 | Arg2 | ENSRNOP00000020940 | ENSRNOP00000073568 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.554 |
Aldh18a1 | Asl | ENSRNOP00000020940 | ENSRNOP00000001211 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.839 |
Aldh18a1 | Ass1 | ENSRNOP00000020940 | ENSRNOP00000076301 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.866 |
Aldh18a1 | Nags | ENSRNOP00000020940 | ENSRNOP00000028332 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | N-acetylglutamate synthase (Predicted), isoform CRA_a. | 0.783 |
Aldh18a1 | Oat | ENSRNOP00000020940 | ENSRNOP00000022628 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine aminotransferase, mitochondrial. | 0.999 |
Aldh18a1 | Odc1 | ENSRNOP00000020940 | ENSRNOP00000007259 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.617 |
Aldh18a1 | Otc | ENSRNOP00000020940 | ENSRNOP00000004686 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.697 |
Aldh18a1 | RGD1562036 | ENSRNOP00000020940 | ENSRNOP00000031505 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.554 |
Aldh18a1-2 | Aldh18a1 | ENSRNOP00000074318 | ENSRNOP00000020940 | Aldehyde dehydrogenase 18 family, member A1. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.999 |
Aldh18a1-2 | Arg1 | ENSRNOP00000074318 | ENSRNOP00000017911 | Aldehyde dehydrogenase 18 family, member A1. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.554 |
Aldh18a1-2 | Arg2 | ENSRNOP00000074318 | ENSRNOP00000073568 | Aldehyde dehydrogenase 18 family, member A1. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.554 |
Aldh18a1-2 | Asl | ENSRNOP00000074318 | ENSRNOP00000001211 | Aldehyde dehydrogenase 18 family, member A1. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.795 |
Aldh18a1-2 | Ass1 | ENSRNOP00000074318 | ENSRNOP00000076301 | Aldehyde dehydrogenase 18 family, member A1. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.831 |
Aldh18a1-2 | Nags | ENSRNOP00000074318 | ENSRNOP00000028332 | Aldehyde dehydrogenase 18 family, member A1. | N-acetylglutamate synthase (Predicted), isoform CRA_a. | 0.783 |
Aldh18a1-2 | Oat | ENSRNOP00000074318 | ENSRNOP00000022628 | Aldehyde dehydrogenase 18 family, member A1. | Ornithine aminotransferase, mitochondrial. | 0.991 |
Aldh18a1-2 | Odc1 | ENSRNOP00000074318 | ENSRNOP00000007259 | Aldehyde dehydrogenase 18 family, member A1. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.554 |
Aldh18a1-2 | Otc | ENSRNOP00000074318 | ENSRNOP00000004686 | Aldehyde dehydrogenase 18 family, member A1. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.605 |
Aldh18a1-2 | RGD1562036 | ENSRNOP00000074318 | ENSRNOP00000031505 | Aldehyde dehydrogenase 18 family, member A1. | Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.554 |