node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fn1 | Itga8 | ENSRNOP00000019772 | ENSRNOP00000022713 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.920 |
Fn1 | Itgb1 | ENSRNOP00000019772 | ENSRNOP00000014785 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.967 |
Fn1 | Itgb3 | ENSRNOP00000019772 | ENSRNOP00000067271 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.611 |
Fn1 | Itgb6 | ENSRNOP00000019772 | ENSRNOP00000074271 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.922 |
Fn1 | Vtn | ENSRNOP00000019772 | ENSRNOP00000075508 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Vitronectin. | 0.976 |
Fras1 | Frem1 | ENSRNOP00000002814 | ENSRNOP00000055412 | Fraser extracellular matrix complex subunit 1. | Fras1-related extracellular matrix 1. | 0.966 |
Fras1 | Frem2 | ENSRNOP00000002814 | ENSRNOP00000031592 | Fraser extracellular matrix complex subunit 1. | FRAS1-related extracellular matrix 2. | 0.958 |
Fras1 | Itga8 | ENSRNOP00000002814 | ENSRNOP00000022713 | Fraser extracellular matrix complex subunit 1. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.932 |
Fras1 | Itgb1 | ENSRNOP00000002814 | ENSRNOP00000014785 | Fraser extracellular matrix complex subunit 1. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.903 |
Frem1 | Fras1 | ENSRNOP00000055412 | ENSRNOP00000002814 | Fras1-related extracellular matrix 1. | Fraser extracellular matrix complex subunit 1. | 0.966 |
Frem1 | Frem2 | ENSRNOP00000055412 | ENSRNOP00000031592 | Fras1-related extracellular matrix 1. | FRAS1-related extracellular matrix 2. | 0.977 |
Frem1 | Itga8 | ENSRNOP00000055412 | ENSRNOP00000022713 | Fras1-related extracellular matrix 1. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.928 |
Frem1 | Itgb1 | ENSRNOP00000055412 | ENSRNOP00000014785 | Fras1-related extracellular matrix 1. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.902 |
Frem1 | Npnt | ENSRNOP00000055412 | ENSRNOP00000074549 | Fras1-related extracellular matrix 1. | Nephronectin. | 0.554 |
Frem2 | Fras1 | ENSRNOP00000031592 | ENSRNOP00000002814 | FRAS1-related extracellular matrix 2. | Fraser extracellular matrix complex subunit 1. | 0.958 |
Frem2 | Frem1 | ENSRNOP00000031592 | ENSRNOP00000055412 | FRAS1-related extracellular matrix 2. | Fras1-related extracellular matrix 1. | 0.977 |
Frem2 | Itga8 | ENSRNOP00000031592 | ENSRNOP00000022713 | FRAS1-related extracellular matrix 2. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.933 |
Frem2 | Itgb1 | ENSRNOP00000031592 | ENSRNOP00000014785 | FRAS1-related extracellular matrix 2. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.906 |
Itga8 | Fn1 | ENSRNOP00000022713 | ENSRNOP00000019772 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | 0.920 |
Itga8 | Fras1 | ENSRNOP00000022713 | ENSRNOP00000002814 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Fraser extracellular matrix complex subunit 1. | 0.932 |