STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RaxRetinal homeobox protein Rx; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE- 1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity). (342 aa)    
Predicted Functional Partners:
Fiz1
Similar to Flt3 interacting zinc finger protein 1 (Predicted).
   
 
 0.656
Zfp865
Similar to zinc finger protein ZFP (Predicted).
  
 
 0.556
Six6
Sine oculis-related homeobox 6 homolog (Drosophila) (Predicted).
   
 
 0.537
Nrl
Neural retina leucine zipper gene (Predicted).
    
 
 0.523
Gpr50
Melatonin-related receptor; Does not bind melatonin.
   
 
 0.507
Six3
SIX homeobox 3.
   
 
 0.488
Cplx4
Complexin 4.
   
  
 0.461
Rarres2
Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a.
   
  
 0.460
Atxn7
Ataxin 7.
    
 
 0.437
Foxd2
Forkhead box protein D1; Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (By similarity).
  
 
 0.421
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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