STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem50aTransmembrane protein 50A. (157 aa)    
Predicted Functional Partners:
Leprot
Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family.
   
 
 0.884
Leprotl1
Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Belongs to the OB-RGRP/VPS55 family.
   
 
 0.879
Npy1r
Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY.
      
 0.630
Slc13a2
Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
      
 0.563
Agtrap
Type-1 angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen- activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.
   
  
 0.539
Nipal2
Similar to RIKEN cDNA 9330161F08 (Predicted), isoform CRA_a.
      
 0.536
Gart
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
      
 0.532
Syf2
Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome.
   
  
 0.480
Rsrp1
Arginine/serine-rich protein 1.
   
  
 0.476
Rhd
Blood group Rh(D) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
      
 0.471
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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