node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1c1 | Akr1c3 | ENSRNOP00000055169 | ENSRNOP00000023739 | Type 5 17beta-hydroxysteroid dehydrogenase. | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 0.907 |
Akr1c1 | Akr1d1 | ENSRNOP00000055169 | ENSRNOP00000017675 | Type 5 17beta-hydroxysteroid dehydrogenase. | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | 0.934 |
Akr1c1 | Cyp11b2 | ENSRNOP00000055169 | ENSRNOP00000049722 | Type 5 17beta-hydroxysteroid dehydrogenase. | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | 0.916 |
Akr1c1 | Cyp17a1 | ENSRNOP00000055169 | ENSRNOP00000027160 | Type 5 17beta-hydroxysteroid dehydrogenase. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.953 |
Akr1c1 | Cyp21a1 | ENSRNOP00000055169 | ENSRNOP00000037516 | Type 5 17beta-hydroxysteroid dehydrogenase. | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | 0.910 |
Akr1c1 | Hsd3b2 | ENSRNOP00000055169 | ENSRNOP00000026306 | Type 5 17beta-hydroxysteroid dehydrogenase. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.948 |
Akr1c1 | Hsd3b5 | ENSRNOP00000055169 | ENSRNOP00000072555 | Type 5 17beta-hydroxysteroid dehydrogenase. | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.929 |
Akr1c1 | Srd5a1 | ENSRNOP00000055169 | ENSRNOP00000023659 | Type 5 17beta-hydroxysteroid dehydrogenase. | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.962 |
Akr1c1 | Srd5a2 | ENSRNOP00000055169 | ENSRNOP00000009254 | Type 5 17beta-hydroxysteroid dehydrogenase. | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). | 0.955 |
Akr1c1 | Srd5a3 | ENSRNOP00000055169 | ENSRNOP00000069749 | Type 5 17beta-hydroxysteroid dehydrogenase. | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT). | 0.943 |
Akr1c3 | Akr1c1 | ENSRNOP00000023739 | ENSRNOP00000055169 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Type 5 17beta-hydroxysteroid dehydrogenase. | 0.907 |
Akr1c3 | Akr1d1 | ENSRNOP00000023739 | ENSRNOP00000017675 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). | 0.912 |
Akr1c3 | Cyp11b2 | ENSRNOP00000023739 | ENSRNOP00000049722 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Cytochrome P450 11B3, mitochondrial; Converts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone; Belongs to the cytochrome P450 family. | 0.923 |
Akr1c3 | Cyp17a1 | ENSRNOP00000023739 | ENSRNOP00000027160 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.957 |
Akr1c3 | Cyp21a1 | ENSRNOP00000023739 | ENSRNOP00000037516 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. | 0.924 |
Akr1c3 | Hsd3b2 | ENSRNOP00000023739 | ENSRNOP00000026306 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.965 |
Akr1c3 | Hsd3b5 | ENSRNOP00000023739 | ENSRNOP00000072555 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.943 |
Akr1c3 | Srd5a1 | ENSRNOP00000023739 | ENSRNOP00000023659 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.970 |
Akr1c3 | Srd5a2 | ENSRNOP00000023739 | ENSRNOP00000009254 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). | 0.966 |
Akr1c3 | Srd5a3 | ENSRNOP00000023739 | ENSRNOP00000069749 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT). | 0.943 |